The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells

This study identifies signaling pathways essential for maintaining the stemness and metastatic potential of colorectal cancer cells and proposes CREB as a therapeutic target in metastatic colorectal cancer.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2022-11, Vol.82 (22), p.4179-4190
Hauptverfasser:	Fujishita, Teruaki, Kojima, Yasushi, Kajino-Sakamoto, Rie, Mishiro-Sato, Emi, Shimizu, Yasuhiro, Hosoda, Waki, Yamaguchi, Rui, Taketo, Makoto Mark, Aoki, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Humans Neoplasm Metastasis - genetics Neoplasm Metastasis - physiopathology Neoplastic Stem Cells - metabolism Signal Transduction Smad4 Protein - genetics Smad4 Protein - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism
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Beschreibung
Zusammenfassung:	This study identifies signaling pathways essential for maintaining the stemness and metastatic potential of colorectal cancer cells and proposes CREB as a therapeutic target in metastatic colorectal cancer.
ISSN:	0008-5472 1538-7445
DOI:	10.1158/0008-5472.CAN-22-1369