Biological Schiff bases may generate reactive triplet carbonyls and singlet oxygen: A model study

Biological Schiff bases may generate reactive triplet carbonyls and singlet oxygen: A model study

[Display omitted] •A model Schiff base reacts with peroxynitrite yielding reactive oxygen species.•Triplet acetone and singlet oxygen are products from the EIBI-peroxynitrite reaction.•The EIBI-peroxynitrite reaction may occur via radical reaction or nucleophilic addition.•Direct- and DBAS-enhanced...

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Veröffentlicht in:Free radical biology & medicine 2022-10, Vol.191, p.97-104
Hauptverfasser: Ramos, Luiz D., Gomes, Thiago M.V., Quintiliano, Samir A.P., Premi, Sanjay, Stevani, Cassius V., Bechara, Etelvino J.H.
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Sprache:eng
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Zusammenfassung:[Display omitted] •A model Schiff base reacts with peroxynitrite yielding reactive oxygen species.•Triplet acetone and singlet oxygen are products from the EIBI-peroxynitrite reaction.•The EIBI-peroxynitrite reaction may occur via radical reaction or nucleophilic addition.•Direct- and DBAS-enhanced chemiluminescence result from excited products.•Unbalanced formation of biological Schiff base may produce deleterious effects.
ISSN:0891-5849
1873-4596
DOI:10.1016/j.freeradbiomed.2022.08.034