Importance of diet in amphibian metamorphosis‐based studies designed to assess the risk of thyroid active substances

Importance of diet in amphibian metamorphosis‐based studies designed to assess the risk of thyroid active substances

The present study evaluated the hypothesis that dietary quality used in historical studies may impact the effects of chemical stressors on premetamorphic development and metamorphosis due to suboptimal nutritional quality. A modified Amphibian Metamorphosis Assay (AMA) was performed in which Nieuwko...

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Veröffentlicht in:Journal of applied toxicology 2023-03, Vol.43 (3), p.360-372
Hauptverfasser: Fort, Douglas J., Leopold, M. Annegaaike, Wolf, Jeffrey C., Todhunter, Kevin J., Weterings, Peter J. J. M.
Format: Artikel
Sprache:eng
Schlagworte:
amphibian
Amphibians
Animals
Benchmarks
Dechlorination
development
Developmental stages
Diet
Diet - adverse effects
Drinking water
Evaluation
Frogs
Iodides
Iodides - pharmacology
Iodine
Larva
Larvae
Metamorphosis
Metamorphosis, Biological
Nutrient deficiency
Nutritive value
Risk assessment
Thyroid
Thyroid Gland
Xenopus laevis
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Zusammenfassung:The present study evaluated the hypothesis that dietary quality used in historical studies may impact the effects of chemical stressors on premetamorphic development and metamorphosis due to suboptimal nutritional quality. A modified Amphibian Metamorphosis Assay (AMA) was performed in which Nieuwkoop and Faber (NF) Stage 47 tadpoles of Xenopus laevis were exposed for 32 days to iodide (I−)‐deficient FETAX solution supplemented with
ISSN:0260-437X
1099-1263
DOI:10.1002/jat.4387