Haplo-Peripheral Blood Stem Cell Plus Cord Blood Grafts for Hematologic Malignancies Might Lead to Lower Relapse Compared with Haplo-Peripheral Blood Stem Cell Plus Bone Marrow Grafts

•Haplo-PBSC+cord transplantation in hematologic malignancies was associated with a lower incidence of 1-year relapse compared with haplo-PBSC+BM transplantation.•Faster platelet engraftment was observed in haplo-PBSC+cord transplantation.•Haplo-PBSC+cord transplantation was associated with superior...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Transplantation and cellular therapy 2022-12, Vol.28 (12), p.849.e1-849.e8
Hauptverfasser: Huang, Fen, Zeng, Xiangzong, Fan, Zhiping, Xu, Na, Yu, Sijian, Xuan, Li, Liu, Hui, Jin, Hua, Lin, Ren, Shi, Pengcheng, Zhao, Ke, Li, Xiaofang, Wei, Xiaolei, Xu, Jun, Wang, Zhixiang, Sun, Jing, Chai, Yanyan, Liu, Qifa
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•Haplo-PBSC+cord transplantation in hematologic malignancies was associated with a lower incidence of 1-year relapse compared with haplo-PBSC+BM transplantation.•Faster platelet engraftment was observed in haplo-PBSC+cord transplantation.•Haplo-PBSC+cord transplantation was associated with superior DFS and OS. To compare the outcomes between peripheral blood stem cell (PBSC)+cord blood and PBSC+bone marrow (BM) grafts in the setting of haploidentical donor (HID) transplantation, 110 patients were enrolled in this retrospective study, including 54 recipients of haplo-PBSC+cord transplants and 56 recipients of haplo-PBSC+BM transplants. Chimerism analyses revealed that by day 30 post-transplantation, 94.3% of surviving patients in the haplo-PBSC+cord group had achieved full haploidentical chimerism and 5.7% had
ISSN:2666-6367
2666-6367
DOI:10.1016/j.jtct.2022.08.025