Haplo-Peripheral Blood Stem Cell Plus Cord Blood Grafts for Hematologic Malignancies Might Lead to Lower Relapse Compared with Haplo-Peripheral Blood Stem Cell Plus Bone Marrow Grafts
•Haplo-PBSC+cord transplantation in hematologic malignancies was associated with a lower incidence of 1-year relapse compared with haplo-PBSC+BM transplantation.•Faster platelet engraftment was observed in haplo-PBSC+cord transplantation.•Haplo-PBSC+cord transplantation was associated with superior...
Gespeichert in:
Veröffentlicht in: | Transplantation and cellular therapy 2022-12, Vol.28 (12), p.849.e1-849.e8 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | •Haplo-PBSC+cord transplantation in hematologic malignancies was associated with a lower incidence of 1-year relapse compared with haplo-PBSC+BM transplantation.•Faster platelet engraftment was observed in haplo-PBSC+cord transplantation.•Haplo-PBSC+cord transplantation was associated with superior DFS and OS.
To compare the outcomes between peripheral blood stem cell (PBSC)+cord blood and PBSC+bone marrow (BM) grafts in the setting of haploidentical donor (HID) transplantation, 110 patients were enrolled in this retrospective study, including 54 recipients of haplo-PBSC+cord transplants and 56 recipients of haplo-PBSC+BM transplants. Chimerism analyses revealed that by day 30 post-transplantation, 94.3% of surviving patients in the haplo-PBSC+cord group had achieved full haploidentical chimerism and 5.7% had |
---|---|
ISSN: | 2666-6367 2666-6367 |
DOI: | 10.1016/j.jtct.2022.08.025 |