Effectiveness of platelet-rich concentrates on the rate of orthodontic tooth movement: a systematic review and meta-analysis

Summary Background Autologous platelet-rich concentrates (PRCs) are recently used as a local biological substance in orthodontics to accelerate the rate of tooth movement. Objectives This systematic review aimed to evaluate the effects of PRCs on the rate of orthodontic tooth movement (OTM). Search methods Unrestricted search of five electronic databases supplemented by the manual and gray literature search were undertaken in March 2022. Selection criteria Randomized controlled trials (RCTs) evaluating the effect of PRCs on the rate of OTM with their side effect were included in this systematic review. Data collection and analysis Data items were extracted by two authors using a pre-piloted extraction form. Similar outcomes within a comparable time frame were synthesized in a meta-analysis. Results Fourteen studies were deemed eligible for inclusion and seven RCTs were pooled in a meta-analysis. Canine retraction rate was higher in the side of PRCs injection than the control side by 0.28 mm/month (95% CI: 0.16–0.40, I2 = 95.6 per cent, P