Photoredox Catalyzed Thioformylation of Terminal Alkynes Using Nitromethane as a Formyl Source

Photoredox Catalyzed Thioformylation of Terminal Alkynes Using Nitromethane as a Formyl Source

A photoredox thioformylation of terminal alkynes using nitromethane as a formyl anion equivalent, thereby leading to the synthesis of (E)-1,2-difunctionalized acrylaldehyde, has been described. The current strategy introduces an adaptable aldehyde function across an alkyne and offers a new route to...

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Veröffentlicht in:Organic letters 2022-09, Vol.24 (36), p.6658-6663
Hauptverfasser: Bhat, Muneer-ul-Shafi, Ganie, Majid Ahmad, Rizvi, Masood Ahmad, Raheem, Shabnam, Shah, Bhahwal Ali
Format: Artikel
Sprache:eng
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Zusammenfassung:A photoredox thioformylation of terminal alkynes using nitromethane as a formyl anion equivalent, thereby leading to the synthesis of (E)-1,2-difunctionalized acrylaldehyde, has been described. The current strategy introduces an adaptable aldehyde function across an alkyne and offers a new route to synthesizing α-alkyl/aryl aldehydes.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c02695