Timing of Vasopressin Addition to Norepinephrine and Efficacy Outcomes in Patients With Septic Shock

Background: Current guidelines recommend norepinephrine as the first-line vasopressor in septic shock followed by addition of vasopressin to achieve a goal mean arterial pressure. Limited evidence exists evaluating how the timing of vasopressin addition affects clinical outcomes in septic shock. Objective: The objective of this study was to determine whether the timing of the addition of vasopressin to norepinephrine affects shock resolution. Methods: This was a multi-site, single system, retrospective cohort, institutional review board (IRB)-approved study examining adult patients with septic shock who received norepinephrine and vasopressin. Patients were divided and statistically analyzed in two subgroups: early vasopressin addition (