Factors affecting prognosis in hepatocellular carcinoma patients post-transarterial chemoembolization
Background To evaluate the factors influencing the achievement of a sustained complete response (CR) and overall survival (OS) in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE). Methods We retrospectively reviewed the records of HCC patients who underwent T...
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| Veröffentlicht in: | Indian journal of gastroenterology 2022-08, Vol.41 (4), p.352-361 |
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| container_title | Indian journal of gastroenterology |
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| creator | Prateepchaiboon, Tanaporn Chang, Arunchai Pungpipattrakul, Nuttanit Akarapatima, Keerati Rattanasupar, Attapon Songjamrat, Apiradee Pakdeejit, Songklod Piratvisuth, Teerha |
| description | Background
To evaluate the factors influencing the achievement of a sustained complete response (CR) and overall survival (OS) in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE).
Methods
We retrospectively reviewed the records of HCC patients who underwent TACE as the first modality of treatment between 2014 and 2019. We investigated the factors affecting sustained CR (no recurrence within 6 months) and OS (time from diagnosis until either death or last follow-up).
Results
The study enrolled 161 patients; 159 (98.8%) had cirrhosis. Post-TACE, 19.9% (32/161) achieved sustained CR. In the multivariate analysis, a tumor size 100 ng/mL (HR 2.082;
p
|
| doi_str_mv | 10.1007/s12664-021-01227-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2707611812</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2707611812</sourcerecordid><originalsourceid>FETCH-LOGICAL-c254t-69000af05dcc7b10895612ec5d920cbc0e49c3f5228c794d7dd77ad737b28d793</originalsourceid><addsrcrecordid>eNp9kDtPwzAUhS0EEqXwB5g8shiunYfjEVW8pEosMFuO47SuEjvYzlB-PS5hZroPfefq3IPQLYV7CsAfImV1XRJglABljJPjGVqB4BUBTul57llVkqap4RJdxXiA0yyKFTLPSicfIlZ9b3Syboen4HfORxuxdXhvJpW8NsMwDypgrYK2zo8K57U1LkU8-ZhICspFFZIJVg1Y783ozdj6wX5nzLtrdNGrIZqbv7pGn89PH5tXsn1_eds8bonOdhKpBQCoHqpOa95SaERVU2Z01QkGutVgSqGLvmKs0VyUHe86zlXHC96ypuOiWKO75W7-4Ws2McnRxpN55Yyfo2QceE1pQ1lG2YLq4GMMppdTsKMKR0lBnjKVS6YyZyp_M5XHLCoWUcyw25kgD34OLr_0n-oHpAF9RA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2707611812</pqid></control><display><type>article</type><title>Factors affecting prognosis in hepatocellular carcinoma patients post-transarterial chemoembolization</title><source>Springer Nature - Complete Springer Journals</source><creator>Prateepchaiboon, Tanaporn ; Chang, Arunchai ; Pungpipattrakul, Nuttanit ; Akarapatima, Keerati ; Rattanasupar, Attapon ; Songjamrat, Apiradee ; Pakdeejit, Songklod ; Piratvisuth, Teerha</creator><creatorcontrib>Prateepchaiboon, Tanaporn ; Chang, Arunchai ; Pungpipattrakul, Nuttanit ; Akarapatima, Keerati ; Rattanasupar, Attapon ; Songjamrat, Apiradee ; Pakdeejit, Songklod ; Piratvisuth, Teerha</creatorcontrib><description>Background
To evaluate the factors influencing the achievement of a sustained complete response (CR) and overall survival (OS) in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE).
Methods
We retrospectively reviewed the records of HCC patients who underwent TACE as the first modality of treatment between 2014 and 2019. We investigated the factors affecting sustained CR (no recurrence within 6 months) and OS (time from diagnosis until either death or last follow-up).
Results
The study enrolled 161 patients; 159 (98.8%) had cirrhosis. Post-TACE, 19.9% (32/161) achieved sustained CR. In the multivariate analysis, a tumor size < 5 cm was a positive factor for achieving sustained CR (odds ratio, 5.012;
p
= 0.006). In the proportional hazards model, the factors associated with decreased survival included alcohol-related liver disease (hazards ratio [HR] 1.683;
p
= 0.036), presence of symptoms (HR 1.816;
p
= 0.005) and portal hypertension (HR 1.608;
p
= 0.038) at initial diagnosis, serum alpha-fetoprotein (AFP) > 100 ng/mL (HR 2.082;
p
< 0.001), and higher Child–Pugh classification (HR 1.1.639;
p
= 0.024). Achievement of sustained CR (HR, 0.355;
p
= 0.002) was independently associated with increased survival.
Conclusions
The tumor size was a predictive factor for sustained CR. Alcohol-related liver disease, presence of symptoms and portal hypertension at initial diagnosis, elevated serum AFP, liver reserve status, and achieved sustained CR were independent factors affecting survival. We demonstrated the effect of alcohol-related liver disease on survival after TACE. Our results will aid physicians in the management and prognostication of HCC.</description><identifier>ISSN: 0254-8860</identifier><identifier>EISSN: 0975-0711</identifier><identifier>DOI: 10.1007/s12664-021-01227-y</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Gastroenterology ; Hepatology ; Medicine ; Medicine & Public Health ; Original Article</subject><ispartof>Indian journal of gastroenterology, 2022-08, Vol.41 (4), p.352-361</ispartof><rights>Indian Society of Gastroenterology 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c254t-69000af05dcc7b10895612ec5d920cbc0e49c3f5228c794d7dd77ad737b28d793</citedby><cites>FETCH-LOGICAL-c254t-69000af05dcc7b10895612ec5d920cbc0e49c3f5228c794d7dd77ad737b28d793</cites><orcidid>0000-0002-0158-2685</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12664-021-01227-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12664-021-01227-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Prateepchaiboon, Tanaporn</creatorcontrib><creatorcontrib>Chang, Arunchai</creatorcontrib><creatorcontrib>Pungpipattrakul, Nuttanit</creatorcontrib><creatorcontrib>Akarapatima, Keerati</creatorcontrib><creatorcontrib>Rattanasupar, Attapon</creatorcontrib><creatorcontrib>Songjamrat, Apiradee</creatorcontrib><creatorcontrib>Pakdeejit, Songklod</creatorcontrib><creatorcontrib>Piratvisuth, Teerha</creatorcontrib><title>Factors affecting prognosis in hepatocellular carcinoma patients post-transarterial chemoembolization</title><title>Indian journal of gastroenterology</title><addtitle>Indian J Gastroenterol</addtitle><description>Background
To evaluate the factors influencing the achievement of a sustained complete response (CR) and overall survival (OS) in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE).
Methods
We retrospectively reviewed the records of HCC patients who underwent TACE as the first modality of treatment between 2014 and 2019. We investigated the factors affecting sustained CR (no recurrence within 6 months) and OS (time from diagnosis until either death or last follow-up).
Results
The study enrolled 161 patients; 159 (98.8%) had cirrhosis. Post-TACE, 19.9% (32/161) achieved sustained CR. In the multivariate analysis, a tumor size < 5 cm was a positive factor for achieving sustained CR (odds ratio, 5.012;
p
= 0.006). In the proportional hazards model, the factors associated with decreased survival included alcohol-related liver disease (hazards ratio [HR] 1.683;
p
= 0.036), presence of symptoms (HR 1.816;
p
= 0.005) and portal hypertension (HR 1.608;
p
= 0.038) at initial diagnosis, serum alpha-fetoprotein (AFP) > 100 ng/mL (HR 2.082;
p
< 0.001), and higher Child–Pugh classification (HR 1.1.639;
p
= 0.024). Achievement of sustained CR (HR, 0.355;
p
= 0.002) was independently associated with increased survival.
Conclusions
The tumor size was a predictive factor for sustained CR. Alcohol-related liver disease, presence of symptoms and portal hypertension at initial diagnosis, elevated serum AFP, liver reserve status, and achieved sustained CR were independent factors affecting survival. We demonstrated the effect of alcohol-related liver disease on survival after TACE. Our results will aid physicians in the management and prognostication of HCC.</description><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><issn>0254-8860</issn><issn>0975-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPwzAUhS0EEqXwB5g8shiunYfjEVW8pEosMFuO47SuEjvYzlB-PS5hZroPfefq3IPQLYV7CsAfImV1XRJglABljJPjGVqB4BUBTul57llVkqap4RJdxXiA0yyKFTLPSicfIlZ9b3Syboen4HfORxuxdXhvJpW8NsMwDypgrYK2zo8K57U1LkU8-ZhICspFFZIJVg1Y783ozdj6wX5nzLtrdNGrIZqbv7pGn89PH5tXsn1_eds8bonOdhKpBQCoHqpOa95SaERVU2Z01QkGutVgSqGLvmKs0VyUHe86zlXHC96ypuOiWKO75W7-4Ws2McnRxpN55Yyfo2QceE1pQ1lG2YLq4GMMppdTsKMKR0lBnjKVS6YyZyp_M5XHLCoWUcyw25kgD34OLr_0n-oHpAF9RA</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Prateepchaiboon, Tanaporn</creator><creator>Chang, Arunchai</creator><creator>Pungpipattrakul, Nuttanit</creator><creator>Akarapatima, Keerati</creator><creator>Rattanasupar, Attapon</creator><creator>Songjamrat, Apiradee</creator><creator>Pakdeejit, Songklod</creator><creator>Piratvisuth, Teerha</creator><general>Springer India</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0158-2685</orcidid></search><sort><creationdate>20220801</creationdate><title>Factors affecting prognosis in hepatocellular carcinoma patients post-transarterial chemoembolization</title><author>Prateepchaiboon, Tanaporn ; Chang, Arunchai ; Pungpipattrakul, Nuttanit ; Akarapatima, Keerati ; Rattanasupar, Attapon ; Songjamrat, Apiradee ; Pakdeejit, Songklod ; Piratvisuth, Teerha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c254t-69000af05dcc7b10895612ec5d920cbc0e49c3f5228c794d7dd77ad737b28d793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prateepchaiboon, Tanaporn</creatorcontrib><creatorcontrib>Chang, Arunchai</creatorcontrib><creatorcontrib>Pungpipattrakul, Nuttanit</creatorcontrib><creatorcontrib>Akarapatima, Keerati</creatorcontrib><creatorcontrib>Rattanasupar, Attapon</creatorcontrib><creatorcontrib>Songjamrat, Apiradee</creatorcontrib><creatorcontrib>Pakdeejit, Songklod</creatorcontrib><creatorcontrib>Piratvisuth, Teerha</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prateepchaiboon, Tanaporn</au><au>Chang, Arunchai</au><au>Pungpipattrakul, Nuttanit</au><au>Akarapatima, Keerati</au><au>Rattanasupar, Attapon</au><au>Songjamrat, Apiradee</au><au>Pakdeejit, Songklod</au><au>Piratvisuth, Teerha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors affecting prognosis in hepatocellular carcinoma patients post-transarterial chemoembolization</atitle><jtitle>Indian journal of gastroenterology</jtitle><stitle>Indian J Gastroenterol</stitle><date>2022-08-01</date><risdate>2022</risdate><volume>41</volume><issue>4</issue><spage>352</spage><epage>361</epage><pages>352-361</pages><issn>0254-8860</issn><eissn>0975-0711</eissn><abstract>Background
To evaluate the factors influencing the achievement of a sustained complete response (CR) and overall survival (OS) in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE).
Methods
We retrospectively reviewed the records of HCC patients who underwent TACE as the first modality of treatment between 2014 and 2019. We investigated the factors affecting sustained CR (no recurrence within 6 months) and OS (time from diagnosis until either death or last follow-up).
Results
The study enrolled 161 patients; 159 (98.8%) had cirrhosis. Post-TACE, 19.9% (32/161) achieved sustained CR. In the multivariate analysis, a tumor size < 5 cm was a positive factor for achieving sustained CR (odds ratio, 5.012;
p
= 0.006). In the proportional hazards model, the factors associated with decreased survival included alcohol-related liver disease (hazards ratio [HR] 1.683;
p
= 0.036), presence of symptoms (HR 1.816;
p
= 0.005) and portal hypertension (HR 1.608;
p
= 0.038) at initial diagnosis, serum alpha-fetoprotein (AFP) > 100 ng/mL (HR 2.082;
p
< 0.001), and higher Child–Pugh classification (HR 1.1.639;
p
= 0.024). Achievement of sustained CR (HR, 0.355;
p
= 0.002) was independently associated with increased survival.
Conclusions
The tumor size was a predictive factor for sustained CR. Alcohol-related liver disease, presence of symptoms and portal hypertension at initial diagnosis, elevated serum AFP, liver reserve status, and achieved sustained CR were independent factors affecting survival. We demonstrated the effect of alcohol-related liver disease on survival after TACE. Our results will aid physicians in the management and prognostication of HCC.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s12664-021-01227-y</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0158-2685</orcidid></addata></record> |
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| subjects | Gastroenterology Hepatology Medicine Medicine & Public Health Original Article |
| title | Factors affecting prognosis in hepatocellular carcinoma patients post-transarterial chemoembolization |
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