Natural history of circulating miRNAs in Duchenne disease: Association with muscle injury and metabolic parameters

Objectives This study aimed to evaluate whether the expression of circulating dystromiRs and a group of oxidative stress‐related (OS‐R) miRNAs is associated with muscle injury and circulating metabolic parameters in Duchenne muscular dystrophy (DMD) patients. Methods Twenty‐four DMD patients were included in this cross‐sectional study. Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR‐1‐3p, miR‐133a‐3p, and miR‐206), and OS‐R miRNAs (miR‐21‐5p, miR‐31‐5p, miR‐128‐3p, and miR‐144‐3p) levels were measured in ambulatory and non‐ambulatory DMD patients. Results DystromiRs (except miR‐1‐3p) and miRNAs OS‐R levels were lower (p‐value