Valeridoids G – Q, Eleven seco‐Iridoids from Valeriana jatamansi and Their Bioactivites

Eleven new seco‐iridoids, valeridoids G‐Q (1–6 and 8–12), along with four known products, 9‐epi‐valtral C (7), desacylbaldrinal (13), 11‐methoxyviburtinal (14) and baldrinal (15), were obtained from Valeriana jatamansi. Among them, the new compounds were identified by their NMR, HR‐ESI‐MS spectroscopic data and ECD calculation. Moreover, valeridoid N and O were a pair of C3 epimers, whose ether bonds between C‐1 and C‐3 opened, and new ether bonds formed between C‐3 and C‐6. Valeridoid Q belonged to the C‐1 degradation of seco‐iridoids. As a result, 9‐epi‐valtral C displayed significant inhibition on Streptococcus agalactiae, Staphylococcus aureus, Staphylococcus argenteus, Shigella flexneri and Klebsiella pneumoniae, and valeridoid Q exhibited the most significant inhibition against Salmonella enteritidis. 9‐Epi‐valtral C and baldrinal selectively inhibited the growth of human glioma stem cells. Valeridoid Q exhibited significant anti‐influenza activity, while valeridoid O inhibited nitric oxide production.