Long noncoding RNA SNHG7‐miRNA‐mRNA axes crosstalk with oncogenic signaling pathways in human cancers

LncRNAs and miRNAs are the two most important non‐coding RNAs, which have been identified to be associated with cancer progression or prevention. The dysregulation of lncRNAs conducts tumorigenesis and metastasis in different ways. One of the mechanisms is that lncRNAs interact with miRNAs to regulate distinct cellular and genomic processes and cancer progression. LncRNA SNHG7 as an oncogene sponges miRNAs and develops lncRNA‐miRNA‐mRNA axes, leading to the regulation of several signaling pathways such as Wnt/β‐Catenin, PI3K/AKT/mTOR, SIRT1, and Snail‐EMT. Therefore, in this article, after a brief overview of lncRNA SNHG7‐miRNA‐mRNA axes' contribution to cancer development, we will discuss the role of lncRNA SNHG7 in the genes expression and signaling pathways related to cancers development via acting as a ceRNA. lncRNA SNHG7 as an oncogene plays its oncogenic function in lncRNA‐miRNA‐mRNA axes basis. Abnormal levels of SNHG7 could sponge miRNA through the cancer‐related signaling pathways, including Wnt/β‐Catenin, PI3K/AKT/mTOR, SIRT1, and Snail‐EMT signaling. Knocking down of SNHG7 could be an approach to reducing oncogenic factors and signaling pathways.