A multifaceted gradient in human cerebellum of structural and functional development

The organization of the basic tissue and functional properties of the cerebellum across development is unknown. Combining several large datasets, we demonstrate in the human cerebellum a static tissue gradient in adults that mirrors a similar growth-rate gradient across development. Quantitative tissue metrics corroborate unique densities of certain lipids and proteins among lobules, and cerebellar structural development closely follows cerebellar functional properties through childhood. The structural and functional development of the human cerebellum is not well known. The cerebellum shows a gradient of tissue properties across its lobules, each of which develops at a unique rate and closely follows changes in function across childhood.