Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50

DNA double-strand breaks (DSBs) threaten genome stability and are linked to tumorigenesis in humans. Repair of DSBs requires the removal of attached proteins and hairpins through a poorly understood but physiologically critical endonuclease activity by the Mre11-Rad50 complex. Here, we report cryoel...

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Veröffentlicht in:	Molecular cell 2022-09, Vol.82 (18), p.3513-3522.e6
Hauptverfasser:	Gut, Fabian, Käshammer, Lisa, Lammens, Katja, Bartho, Joseph D., Boggusch, Anna-Maria, van de Logt, Erik, Kessler, Brigitte, Hopfner, Karl-Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases - genetics Acid Anhydride Hydrolases - metabolism Adenosine Triphosphate - metabolism Cryoelectron Microscopy DNA - metabolism DNA double-strand breaks DNA Repair DNA-Binding Proteins - metabolism DNA-protein complex Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Endonucleases - genetics Exodeoxyribonucleases - genetics Exodeoxyribonucleases - metabolism Humans MRE11 Homologue Protein - chemistry Mre11-Rad50 nuclease Nucleic Acid Conformation SbcCD
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