Helper-Polymer Based Five-Element Nanoparticles (FNPs) for Lung-Specific mRNA Delivery with Long-Term Stability after Lyophilization

Lipid nanoparticles (LNPs) carrying therapeutic mRNAs hold great promise in treating lung-associated diseases like viral infections, tumors, and genetic disorders. However, because of their thermodynamically unstable nature, traditional LNPs carrying mRNAs need to be stored at low temperatures, whic...

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Veröffentlicht in:	Nano letters 2022-08, Vol.22 (16), p.6580-6589
Hauptverfasser:	Cao, Yan, He, Zongxing, Chen, Qimingxing, He, Xiaoyan, Su, Lili, Yu, Wenxia, Zhang, Mingming, Yang, Huiying, Huang, Xingxu, Li, Jianfeng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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