Rh(III)-Catalyzed Tandem Reaction Access to (Quinazolin-2-yl)methanone Derivatives from 2,1-Benzisoxazoles and α‑Azido Ketones

A Rh­(III)-catalyzed tandem reaction for the synthesis of (quinazolin-2-yl)­methanone derivatives has been explored from 2,1-benzisoxazoles and α-azido ketones. The transformation involves Rh­(III)-catalyzed denitrogenation of α-azido ketones, aza-[4 + 2] cycloaddition, ring opening, and dehydration aromatization processes. Notably, the aza-[4 + 2] cycloaddition of an imine rhodium complex intermediate with 2,1-benzisoxazoles is the key to this reaction.