Ionizing radiation damage and repair from 3D-genomic perspective

Ionizing radiation damage and repair from 3D-genomic perspective

Ionizing radiation (IR)-induced DNA damage and repair are complex and occur at hierarchical chromatin structures; radiobiology needs to be studied from a 3D-genomic perspective. Differences in IR damage and repair throughout the 3D genome may help to explain differences in radiosensitivity.

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Veröffentlicht in:Trends in genetics 2023-01, Vol.39 (1), p.1-4
Hauptverfasser: Zheng, Yang, Li, Hao, Bo, Xiaochen, Chen, Hebing
Format: Artikel
Sprache:eng
Schlagworte:
3D genome
DNA Damage - genetics
DNA Repair - genetics
Genomics
ionizing radiation
Radiation Tolerance - genetics
Radiation, Ionizing
radiosensitivity
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Zusammenfassung:Ionizing radiation (IR)-induced DNA damage and repair are complex and occur at hierarchical chromatin structures; radiobiology needs to be studied from a 3D-genomic perspective. Differences in IR damage and repair throughout the 3D genome may help to explain differences in radiosensitivity.
ISSN:0168-9525
DOI:10.1016/j.tig.2022.07.004