Updates in 2022 on the staging of testicular germ cell tumors

Testicular cancer is the most common solid neoplasm of adult men between the ages of 20 and 40 years. Germ cell tumors account for 95% of all testicular tumors. The assessment of staging is essential to guide further management of patients with testicular cancer and to prognosticate cancer-related o...

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Veröffentlicht in:Human pathology 2022-10, Vol.128, p.152-160
Hauptverfasser: Canete Portillo, Sofia, Rais-Bahrami, Soroush, Magi-Galluzzi, Cristina
Format: Artikel
Sprache:eng
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Zusammenfassung:Testicular cancer is the most common solid neoplasm of adult men between the ages of 20 and 40 years. Germ cell tumors account for 95% of all testicular tumors. The assessment of staging is essential to guide further management of patients with testicular cancer and to prognosticate cancer-related outcomes. Postradical orchiectomy treatment options, including adjuvant therapy and active surveillance, vary based on the anatomical extent of disease, serum tumor markers, pathologic diagnosis, and imaging. This review provides an update on the germ cell tumor staging system adopted by the 8th edition of the American Joint Commission on Cancer (AJCC) Staging Manual, treatment implications, risk factors, and predictors of outcomes.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2022.07.009