Reduction of carotid baroreceptor sensitivity in systemic sclerosis
OBJECTIVESSystemic sclerosis (SSc) is an autoimmune disease characterised by diffuse vasculopathy and fibrosis of skin and visceral organs. Moreover, autonomic dysfunction is also suggested as an important step during the multifactorial SSc pathogenesis. Baroreceptors are responsible for maintaining...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2022-10, Vol.40 (10), p.1964-1969 |
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| container_end_page | 1969 |
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| container_issue | 10 |
| container_start_page | 1964 |
| container_title | Clinical and experimental rheumatology |
| container_volume | 40 |
| creator | Colaci, Michele Zanoli, Luca La Malfa, Lara Caruso, Rossella De Andres, Maria Ilenia Sambataro, Domenico Sambataro, Gianluca Castellino, Pietro Malatino, Lorenzo |
| description | OBJECTIVESSystemic sclerosis (SSc) is an autoimmune disease characterised by diffuse vasculopathy and fibrosis of skin and visceral organs. Moreover, autonomic dysfunction is also suggested as an important step during the multifactorial SSc pathogenesis. Baroreceptors are responsible for maintaining blood pressure by means of autonomic system modulation. Considering that autonomic dysfunction and arteriosclerosis can both reduce baroreceptor sensitivity (BRS), in this cross-sectional study we investigated BRS in SSc patients. METHODSTwenty-one SSc patients (mean age 55±10 years, 18 females) and 147 age/sex-matched healthy controls were recruited for the study. BRS (ms/mmHg) was measured by a Finapres® Midi device (Finapres Medical Systems, Amsterdam, The Netherlands). Other parameters were measured: blood pressure, heart rate, heart rate variability triangular index (HRVI), intima-media thickness (IMT), carotid distensibility and pulse wave velocity (PWV). RESULTSBRS was significantly lower in SSc patients compared to controls (6.3±3.3 vs. 10.7±6.8 ms/mmHg; p=0.004). IMT was comparable between SSc and controls, whereas carotid distensibility was lower in SSc (20.1±7.6 vs. 26.6±13.3 KPa-1·10-3; p=0.02) and PWV higher in SSc (8.4±1.3 vs. 7.1±1.1 m/sec; p=0.01). Furthermore, HRVI was lower in SSc (4.5±2.1 vs. 7.5±2.8; p |
| doi_str_mv | 10.55563/clinexprheumatol/4j6028 |
| format | Article |
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Moreover, autonomic dysfunction is also suggested as an important step during the multifactorial SSc pathogenesis. Baroreceptors are responsible for maintaining blood pressure by means of autonomic system modulation. Considering that autonomic dysfunction and arteriosclerosis can both reduce baroreceptor sensitivity (BRS), in this cross-sectional study we investigated BRS in SSc patients. METHODSTwenty-one SSc patients (mean age 55±10 years, 18 females) and 147 age/sex-matched healthy controls were recruited for the study. BRS (ms/mmHg) was measured by a Finapres® Midi device (Finapres Medical Systems, Amsterdam, The Netherlands). Other parameters were measured: blood pressure, heart rate, heart rate variability triangular index (HRVI), intima-media thickness (IMT), carotid distensibility and pulse wave velocity (PWV). RESULTSBRS was significantly lower in SSc patients compared to controls (6.3±3.3 vs. 10.7±6.8 ms/mmHg; p=0.004). IMT was comparable between SSc and controls, whereas carotid distensibility was lower in SSc (20.1±7.6 vs. 26.6±13.3 KPa-1·10-3; p=0.02) and PWV higher in SSc (8.4±1.3 vs. 7.1±1.1 m/sec; p=0.01). Furthermore, HRVI was lower in SSc (4.5±2.1 vs. 7.5±2.8; p<0.001). BRS impairment was independent from age and carotid distensibility in SSc patients, suggesting that BRS dysfunction could be only partially a consequence of SSc vasculopathy. CONCLUSIONSBRS was reduced in SSc patients compared with healthy controls. This finding could represent a SSc-related alteration involving the autonomic system, besides being the mere consequence of sclerodermic vasculopathy.</description><identifier>ISSN: 1593-098X</identifier><identifier>ISSN: 0392-856X</identifier><identifier>EISSN: 1593-098X</identifier><identifier>DOI: 10.55563/clinexprheumatol/4j6028</identifier><language>eng</language><ispartof>Clinical and experimental rheumatology, 2022-10, Vol.40 (10), p.1964-1969</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Colaci, Michele</creatorcontrib><creatorcontrib>Zanoli, Luca</creatorcontrib><creatorcontrib>La Malfa, Lara</creatorcontrib><creatorcontrib>Caruso, Rossella</creatorcontrib><creatorcontrib>De Andres, Maria Ilenia</creatorcontrib><creatorcontrib>Sambataro, Domenico</creatorcontrib><creatorcontrib>Sambataro, Gianluca</creatorcontrib><creatorcontrib>Castellino, Pietro</creatorcontrib><creatorcontrib>Malatino, Lorenzo</creatorcontrib><title>Reduction of carotid baroreceptor sensitivity in systemic sclerosis</title><title>Clinical and experimental rheumatology</title><description>OBJECTIVESSystemic sclerosis (SSc) is an autoimmune disease characterised by diffuse vasculopathy and fibrosis of skin and visceral organs. Moreover, autonomic dysfunction is also suggested as an important step during the multifactorial SSc pathogenesis. Baroreceptors are responsible for maintaining blood pressure by means of autonomic system modulation. Considering that autonomic dysfunction and arteriosclerosis can both reduce baroreceptor sensitivity (BRS), in this cross-sectional study we investigated BRS in SSc patients. METHODSTwenty-one SSc patients (mean age 55±10 years, 18 females) and 147 age/sex-matched healthy controls were recruited for the study. BRS (ms/mmHg) was measured by a Finapres® Midi device (Finapres Medical Systems, Amsterdam, The Netherlands). Other parameters were measured: blood pressure, heart rate, heart rate variability triangular index (HRVI), intima-media thickness (IMT), carotid distensibility and pulse wave velocity (PWV). RESULTSBRS was significantly lower in SSc patients compared to controls (6.3±3.3 vs. 10.7±6.8 ms/mmHg; p=0.004). IMT was comparable between SSc and controls, whereas carotid distensibility was lower in SSc (20.1±7.6 vs. 26.6±13.3 KPa-1·10-3; p=0.02) and PWV higher in SSc (8.4±1.3 vs. 7.1±1.1 m/sec; p=0.01). Furthermore, HRVI was lower in SSc (4.5±2.1 vs. 7.5±2.8; p<0.001). BRS impairment was independent from age and carotid distensibility in SSc patients, suggesting that BRS dysfunction could be only partially a consequence of SSc vasculopathy. CONCLUSIONSBRS was reduced in SSc patients compared with healthy controls. This finding could represent a SSc-related alteration involving the autonomic system, besides being the mere consequence of sclerodermic vasculopathy.</description><issn>1593-098X</issn><issn>0392-856X</issn><issn>1593-098X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkEtLxDAYRYMoOI7-hyzd1MmjeXQpg4-BAUEU3IU0_YIZ2qYmqTj_3sFxIa7OXVwul4MQpuRGCCH5yvVhhK8pvcM82BL7Vb2ThOkTtKCi4RVp9Nvpn3yOLnLeEcKkkGqB1s_Qza6EOOLosbMpltDh9sAEDqYSE84w5lDCZyh7HEac97nAEBzOrocUc8iX6MzbPsPVL5fo9f7uZf1YbZ8eNuvbbeWYVqVStm0Vc5poTWnLvCettE5Kp7lqai_rjna6rYUiSkOrhW9qoLxxHddQK674El0fd6cUP2bIxQwhO-h7O0Kcs2GyUVxqzfihqo9Vd3iYE3gzpTDYtDeUmB9v5r83c_TGvwESpWjL</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Colaci, Michele</creator><creator>Zanoli, Luca</creator><creator>La Malfa, Lara</creator><creator>Caruso, Rossella</creator><creator>De Andres, Maria Ilenia</creator><creator>Sambataro, Domenico</creator><creator>Sambataro, Gianluca</creator><creator>Castellino, Pietro</creator><creator>Malatino, Lorenzo</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20221001</creationdate><title>Reduction of carotid baroreceptor sensitivity in systemic sclerosis</title><author>Colaci, Michele ; Zanoli, Luca ; La Malfa, Lara ; Caruso, Rossella ; De Andres, Maria Ilenia ; Sambataro, Domenico ; Sambataro, Gianluca ; Castellino, Pietro ; Malatino, Lorenzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-7abb72c808811b2ff0b6ac66c83794f64d1d8b457078eb85f94e139cd38e47373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colaci, Michele</creatorcontrib><creatorcontrib>Zanoli, Luca</creatorcontrib><creatorcontrib>La Malfa, Lara</creatorcontrib><creatorcontrib>Caruso, Rossella</creatorcontrib><creatorcontrib>De Andres, Maria Ilenia</creatorcontrib><creatorcontrib>Sambataro, Domenico</creatorcontrib><creatorcontrib>Sambataro, Gianluca</creatorcontrib><creatorcontrib>Castellino, Pietro</creatorcontrib><creatorcontrib>Malatino, Lorenzo</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colaci, Michele</au><au>Zanoli, Luca</au><au>La Malfa, Lara</au><au>Caruso, Rossella</au><au>De Andres, Maria Ilenia</au><au>Sambataro, Domenico</au><au>Sambataro, Gianluca</au><au>Castellino, Pietro</au><au>Malatino, Lorenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction of carotid baroreceptor sensitivity in systemic sclerosis</atitle><jtitle>Clinical and experimental rheumatology</jtitle><date>2022-10-01</date><risdate>2022</risdate><volume>40</volume><issue>10</issue><spage>1964</spage><epage>1969</epage><pages>1964-1969</pages><issn>1593-098X</issn><issn>0392-856X</issn><eissn>1593-098X</eissn><abstract>OBJECTIVESSystemic sclerosis (SSc) is an autoimmune disease characterised by diffuse vasculopathy and fibrosis of skin and visceral organs. Moreover, autonomic dysfunction is also suggested as an important step during the multifactorial SSc pathogenesis. Baroreceptors are responsible for maintaining blood pressure by means of autonomic system modulation. Considering that autonomic dysfunction and arteriosclerosis can both reduce baroreceptor sensitivity (BRS), in this cross-sectional study we investigated BRS in SSc patients. METHODSTwenty-one SSc patients (mean age 55±10 years, 18 females) and 147 age/sex-matched healthy controls were recruited for the study. BRS (ms/mmHg) was measured by a Finapres® Midi device (Finapres Medical Systems, Amsterdam, The Netherlands). Other parameters were measured: blood pressure, heart rate, heart rate variability triangular index (HRVI), intima-media thickness (IMT), carotid distensibility and pulse wave velocity (PWV). RESULTSBRS was significantly lower in SSc patients compared to controls (6.3±3.3 vs. 10.7±6.8 ms/mmHg; p=0.004). IMT was comparable between SSc and controls, whereas carotid distensibility was lower in SSc (20.1±7.6 vs. 26.6±13.3 KPa-1·10-3; p=0.02) and PWV higher in SSc (8.4±1.3 vs. 7.1±1.1 m/sec; p=0.01). Furthermore, HRVI was lower in SSc (4.5±2.1 vs. 7.5±2.8; p<0.001). BRS impairment was independent from age and carotid distensibility in SSc patients, suggesting that BRS dysfunction could be only partially a consequence of SSc vasculopathy. CONCLUSIONSBRS was reduced in SSc patients compared with healthy controls. This finding could represent a SSc-related alteration involving the autonomic system, besides being the mere consequence of sclerodermic vasculopathy.</abstract><doi>10.55563/clinexprheumatol/4j6028</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Alma/SFX Local Collection |
| title | Reduction of carotid baroreceptor sensitivity in systemic sclerosis |
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