Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis

•CRP, IL-6 and TNF-α levels were reduced following omega-3 polyunsaturated fatty acids supplementation.•n-3 PUFA in studies with intervention duration of ≤ 10 weeks causes a profound reduction in IL-6 levels.•n-3 PUFA supplementation a greater decrease in CRP level in pateints with diabetes and with > 55 years of age. Existing meta-analyses on omega-3 polyunsaturated fatty acids and their anti-inflammatory effects have reported uncertain findings. The current umbrella meta-analysis aimed to assess the findings of multiple meta-analyses on the efficacy of n-3 PUFAs on inflammatory biomarkers in adults with different health conditions. Using suitable keywords, articles published until December 2021 were searched in PubMed/Medline, Web of Science, Scopus, EMBASE, and Google Scholar. Meta-analyses investigating the impact of supplementation of n-3 PUFAs on inflammatory biomarkers in adults were included. We performed this meta-analysis using a random-effects model. Overall, 32 meta-analyses were qualified in this umbrella meta-analysis. Our findings demonstrated that the n-3 PUFA supplementation significantly reduced serum C-reactive protein (CRP) (ES = −0.40; 95 % CI: −0.56, −0.24, p