Association of maternal MTHFD1 and MTHFD2 gene polymorphisms with congenital heart disease in offspring

To study the association of maternal methylenetetrahydrofolate dehydrogenase 1 ( ) and methylenetetrahydrofolate dehydrogenase 2 ( ) gene polymorphisms with congenital heart disease (CHD) in offspring. A hospital-based case-control study was conducted. The mothers of 683 children with CHD alone who...

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Veröffentlicht in:Zhongguo dang dai er ke za zhi 2022-07, Vol.24 (7), p.797
Hauptverfasser: Chen, Qian, Huang, Peng, Song, Xin-Li, Liu, Yi-Ping, Sun, Meng-Ting, Wang, Ting-Ting, Zhang, Sen-Mao, Qin, Jia-Bi
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Sprache:chi
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Zusammenfassung:To study the association of maternal methylenetetrahydrofolate dehydrogenase 1 ( ) and methylenetetrahydrofolate dehydrogenase 2 ( ) gene polymorphisms with congenital heart disease (CHD) in offspring. A hospital-based case-control study was conducted. The mothers of 683 children with CHD alone who attended Hunan Children's Hospital, from November 2017 to March 2020 were enrolled as the case group, and the mothers of 740 healthy children who attended the same hospital during the same period and did not have any deformity were enrolled as the control group. A questionnaire survey was performed to collect related exposure data, and then venous blood samples (5 mL) were collected from the mothers to detect and gene polymorphisms. A multivariate logistic regression analysis was used to evaluate the association of and gene polymorphisms with CHD. The four-gamete test in Haploview 4.2 software was used to construct haplotypes and evaluate the association between haplotypes and CHD. The generalized multifactor dimen
ISSN:1008-8830
DOI:10.7499/j.issn.1008-8830.2203002