Exploring the pathophysiology of LARS after low anterior resection for rectal cancer with high‐resolution colon manometry
Background A total mesorectal excision for rectal cancer—although nerve‐ and sphincter‐sparing—can give rise to significant bowel symptoms, commonly referred to as low anterior resection syndrome (LARS). The exact pathophysiology of this syndrome still remains largely unknown, and the impact of radi...
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Veröffentlicht in: | Neurogastroenterology and motility 2022-11, Vol.34 (11), p.e14432-n/a |
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Sprache: | eng |
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Zusammenfassung: | Background
A total mesorectal excision for rectal cancer—although nerve‐ and sphincter‐sparing—can give rise to significant bowel symptoms, commonly referred to as low anterior resection syndrome (LARS). The exact pathophysiology of this syndrome still remains largely unknown, and the impact of radical surgery on colonic motility has only been scarcely investigated.
Methods
High‐resolution colon manometry was performed in patients, 12–24 months after restoration of transit. Patients were divided into two groups: patients with major LARS and no/minor LARS, according to the LARS‐score. Colonic motor patterns were compared, and the relationship of these patterns with the LARS‐scores was investigated.
Key Results
Data were analyzed in 18 patients (9 no/minor LARS, 9 major LARS). Cyclic short antegrade motor patterns did occur more in patients with major LARS (total: p = 0.022; post‐bisacodyl: p = 0.004) and were strongly correlated to LARS‐scores after administering bisacodyl (p |
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ISSN: | 1350-1925 1365-2982 |
DOI: | 10.1111/nmo.14432 |