Comparing radiolytic production of H2O2 and development of Zebrafish embryos after ultra high dose rate exposure with electron and transmission proton beams

Comparing radiolytic production of H2O2 and development of Zebrafish embryos after ultra high dose rate exposure with electron and transmission proton beams

The physico-chemical and biological response to conventional and UHDR electron and proton beams was investigated, along with conventional photons. The temporal structure and nature of the beam affected both, with electron beam at ≥1400 Gy/s and proton beam at 0.1 and 1260 Gy/s found to be isoefficie...

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Veröffentlicht in:Radiotherapy and oncology 2022-10, Vol.175, p.197-202
Hauptverfasser: Kacem, Houda, Psoroulas, Serena, Boivin, Gael, Folkerts, Michael, Grilj, Veljko, Lomax, Tony, Martinotti, Adrien, Meer, David, Ollivier, Jonathan, Petit, Benoit, Safai, Sairos, Sharma, Ricky A., Togno, Michele, Vilalta, Marta, Weber, Damien C., Vozenin, Marie-Catherine
Format: Artikel
Sprache:eng
Schlagworte:
Electron FLASH
Hydrogen peroxyde
Proton FLASH
Zebrafish embryos
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Beschreibung
Zusammenfassung:The physico-chemical and biological response to conventional and UHDR electron and proton beams was investigated, along with conventional photons. The temporal structure and nature of the beam affected both, with electron beam at ≥1400 Gy/s and proton beam at 0.1 and 1260 Gy/s found to be isoefficient at sparing zebrafish embryos.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2022.07.011