Suppression of PI3K/Akt/mTOR Signaling Pathway and Antioxidant System and Reversal of Cancer Cells Resistance to Cisplatin under the Effect of Curcumin

The effect of curcumin on the resistance of SKOV-3 human ovarian adenocarcinoma cells to cisplatin was studied. It was found that curcumin induced “reversal” of cancer cells resistance, which was associated with suppression of the expression of genes encoding the key antioxidant enzymes ( SOD1 , SOD...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2022-07, Vol.173 (3), p.371-375
Hauptverfasser:	Kalinina, E. V., Hasan, A. A. Sh, Tatarskiy, V. V., Volodina, Yu. L., Petrova, А. S., Novichkova, M. D., Zhdanov, D. D., Nurmuradov, N. K., Chernov, N. N., Shtil, A. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adenocarcinoma AKT protein Antioxidants Apoptosis Biomedical and Life Sciences Biomedicine Cancer Cancer cells Cell Biology Cell cycle Cell death Chemotherapy Cisplatin Curcumin Drug resistance Enzymes Gene expression Genes Genetic transcription Internal Medicine Kinases Laboratory Medicine Ovarian cancer Pathology Signal transduction Superoxide dismutase TOR protein Tumors
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Zusammenfassung:	The effect of curcumin on the resistance of SKOV-3 human ovarian adenocarcinoma cells to cisplatin was studied. It was found that curcumin induced “reversal” of cancer cells resistance, which was associated with suppression of the expression of genes encoding the key antioxidant enzymes ( SOD1 , SOD2 , CAT , GPX1 , and HO-1 ) and transcription factor Nrf2 and a decrease in the expression of genes encoding kinases of the PI3K/Akt/mTOR signaling pathway. The obtained results confirm the role of redox-dependent regulation in the “reversal” of cancer cells resistance to cisplatin.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-022-05551-x