New genetic loci associated with the risk of clonal hematopoiesis

New genetic loci associated with the risk of clonal hematopoiesis

Genetic and phenotypic analyses of data from over 400,000 participants in the UK Biobank identified 10 new loci associated with the development of clonal hematopoiesis and implicated DNA damage, oncogene signaling, telomere maintenance and blood cell homing in its pathogenesis. These findings can he...

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Veröffentlicht in:Nature genetics 2022-08, Vol.54 (8), p.1072-1073
Hauptverfasser: Vassiliou, George S, Kar, Siddhartha P
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Agriculture
Animal Genetics and Genomics
Biobanks
Biomedical and Life Sciences
Biomedicine
Blood cancer
Cancer Research
Clonal Hematopoiesis - genetics
Clone Cells
Collaboration
COVID-19
Disease
DNA damage
Epigenetics
Evolution
Fibrillation
Gene Function
Gene loci
Genetic analysis
Genetic Loci
Genomes
Health risk assessment
Hematology
Hematopoiesis - genetics
Human Genetics
Leukocytes
Mutation
Pandemics
Pathogenesis
Research Briefing
Stem cells
Telomeres
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Zusammenfassung:Genetic and phenotypic analyses of data from over 400,000 participants in the UK Biobank identified 10 new loci associated with the development of clonal hematopoiesis and implicated DNA damage, oncogene signaling, telomere maintenance and blood cell homing in its pathogenesis. These findings can help to decipher the pathogenesis of clonal hematopoiesis and develop therapeutic approaches.
ISSN:1061-4036
1546-1718
DOI:10.1038/s41588-022-01125-9