Changes in the expression of meteorin‐like (METRNL), irisin (FNDC5), and uncoupling proteins (UCPs) after bariatric surgery

Abtract Objective Bariatric surgery is currently the most effective treatment for severe obesity. This study aims to investigate the changes in expression levels of meteorin‐like protein (METRNL), irisin (FNDC5), and uncoupling proteins (UCP) 1/2/3 following bariatric surgery to understand their involvement in enhancing metabolism after surgery. Method A total of 40 participants were enrolled in this interventional study, 20 with obesity BMI ≥ 35 kg/m2 and 20 with BMI ≤ 25 kg/m2. Bariatric surgery (laparoscopic sleeve gastrectomy and Roux‐en‐Y gastric bypass) was performed. The levels of various molecules of interest were analyzed before and after surgery. Results Gene expression analysis revealed significantly higher levels of METRNL, UCP1, and UCP3 in individuals with obesity when compared with healthy individuals before surgery (p