The Role of Vitamin D for Modulating the T Helper 1 Immune Response After the Coronavac Vaccination
The purpose of this study was to observe the role of vitamin D levels with T helper 1 (Th1)-type cytokines, such as interferon γ (IFN-γ) and interleukin-12 (IL-12) efficacy, in those who had already received 2 injections of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vacc...
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| Veröffentlicht in: | Journal of interferon & cytokine research 2022-07, Vol.42 (7), p.329-335 |
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| container_title | Journal of interferon & cytokine research |
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| creator | Hanggara, Dian Sukma Iskandar, Agustin Susianti, Hani Wahono, Cesarius Singgih Pratama, Mirza Zaka Nugraha, Aditya Satriya Wibawa, Purwa Adrianta Kesuma, Tanti Adelia Sekarani, Ayu Handono, Kusworini Rahman, Perdana Aditya Anshory, Muhammad |
| description | The purpose of this study was to observe the role of vitamin D levels with T helper 1 (Th1)-type cytokines, such as interferon γ (IFN-γ) and interleukin-12 (IL-12) efficacy, in those who had already received 2 injections of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccines (CoronaVac). We also observed if these cytokines played any significance in the CoronaVac effectiveness for preventing coronavirus disease 2019 (Covid-19) infection. One hundred ninety-four volunteers were monitored for 8 months upon receiving 2 inactivated SARS-CoV2 vaccination injections (CoronaVac, Sinovac Life Sciences). The rate of confirmed Covid-19 infections was the primary outcome. Six to 7 weeks after the second vaccine injection, and blood samples were obtained to measure the serum vitamin D, IFN-γ, and IL-12 levels. Low vitamin D level was defined if vitamin D level |
| doi_str_mv | 10.1089/jir.2021.0218 |
| format | Article |
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We also observed if these cytokines played any significance in the CoronaVac effectiveness for preventing coronavirus disease 2019 (Covid-19) infection. One hundred ninety-four volunteers were monitored for 8 months upon receiving 2 inactivated SARS-CoV2 vaccination injections (CoronaVac, Sinovac Life Sciences). The rate of confirmed Covid-19 infections was the primary outcome. Six to 7 weeks after the second vaccine injection, and blood samples were obtained to measure the serum vitamin D, IFN-γ, and IL-12 levels. Low vitamin D level was defined if vitamin D level <30 ng/mL. Subjects with low vitamin D had lower IFN-γ and IL-12 levels (P = 0.04 and P = 0.04, respectively). The receiver operating characteristics curve analysis revealed that the area under curve for IFN-γ was 0.59, whereas IL-12 was 0.59 for predicting the low vitamin D levels. During follow-up, a higher incidence of Covid-19 infections was observed in subjects with low IFN-γ levels (P = 0.03). Kaplan–Meier survival analysis revealed that the cumulative hazard of confirmed Covid-19 cases was increased in subjects with low IFN-γ levels (log-rank test, P = 0.03). We concluded that lower vitamin D level was correlated with a lower Th1 immune response, whereas the adequate IFN-γ level was required to obtain better CoronaVac effectiveness.</description><identifier>ISSN: 1079-9907</identifier><identifier>EISSN: 1557-7465</identifier><identifier>DOI: 10.1089/jir.2021.0218</identifier><language>eng</language><publisher>New Rochelle: Mary Ann Liebert, Inc</publisher><subject>Calciferol ; Coronaviruses ; COVID-19 ; COVID-19 vaccines ; Cytokines ; Deactivation ; Immune response ; Immune system ; Infections ; Interferon ; Interleukin 12 ; Lymphocytes T ; Rank tests ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Survival analysis ; Vaccines ; Viral diseases ; Vitamin D ; γ-Interferon</subject><ispartof>Journal of interferon & cytokine research, 2022-07, Vol.42 (7), p.329-335</ispartof><rights>Copyright Mary Ann Liebert, Inc. 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We also observed if these cytokines played any significance in the CoronaVac effectiveness for preventing coronavirus disease 2019 (Covid-19) infection. One hundred ninety-four volunteers were monitored for 8 months upon receiving 2 inactivated SARS-CoV2 vaccination injections (CoronaVac, Sinovac Life Sciences). The rate of confirmed Covid-19 infections was the primary outcome. Six to 7 weeks after the second vaccine injection, and blood samples were obtained to measure the serum vitamin D, IFN-γ, and IL-12 levels. Low vitamin D level was defined if vitamin D level <30 ng/mL. Subjects with low vitamin D had lower IFN-γ and IL-12 levels (P = 0.04 and P = 0.04, respectively). The receiver operating characteristics curve analysis revealed that the area under curve for IFN-γ was 0.59, whereas IL-12 was 0.59 for predicting the low vitamin D levels. During follow-up, a higher incidence of Covid-19 infections was observed in subjects with low IFN-γ levels (P = 0.03). Kaplan–Meier survival analysis revealed that the cumulative hazard of confirmed Covid-19 cases was increased in subjects with low IFN-γ levels (log-rank test, P = 0.03). We concluded that lower vitamin D level was correlated with a lower Th1 immune response, whereas the adequate IFN-γ level was required to obtain better CoronaVac effectiveness.</description><subject>Calciferol</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 vaccines</subject><subject>Cytokines</subject><subject>Deactivation</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Infections</subject><subject>Interferon</subject><subject>Interleukin 12</subject><subject>Lymphocytes T</subject><subject>Rank tests</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Survival analysis</subject><subject>Vaccines</subject><subject>Viral diseases</subject><subject>Vitamin D</subject><subject>γ-Interferon</subject><issn>1079-9907</issn><issn>1557-7465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkE1LAzEQhoMoWKtH7wEvXrbmY5PdHEv9aKEiSO01hHSiW3aTNdkV_Pdm0ZOHYYbheYfhQeiakgUltbo7NnHBCKOLXPUJmlEhqqIqpTjNM6lUoRSpztFFSkdCiKyZmiG7-wD8GlrAweF9M5iu8fgeuxDxcziMrRka_46HDO3wGtoeIqZ403WjzzFIffAJ8NINeT9BqxCDN1_G4r2xtvE5HvwlOnOmTXD11-fo7fFht1oX25enzWq5LSxj9VA4KllJDsBLAdJCLQ21wiknmWJ5MIJZy40E4g6cK-OsK4ktM89LJ62gfI5uf-_2MXyOkAbdNclC2xoPYUyaSUWJKEUlM3rzDz2GMfr8XaZqxSirqypTxS9lY0gpgtN9bDoTvzUlelKus3I9KdeTcv4DzGpzhQ</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Hanggara, Dian Sukma</creator><creator>Iskandar, Agustin</creator><creator>Susianti, Hani</creator><creator>Wahono, Cesarius Singgih</creator><creator>Pratama, Mirza Zaka</creator><creator>Nugraha, Aditya Satriya</creator><creator>Wibawa, Purwa Adrianta</creator><creator>Kesuma, Tanti Adelia</creator><creator>Sekarani, Ayu</creator><creator>Handono, Kusworini</creator><creator>Rahman, Perdana Aditya</creator><creator>Anshory, Muhammad</creator><general>Mary Ann Liebert, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9053-545X</orcidid></search><sort><creationdate>20220701</creationdate><title>The Role of Vitamin D for Modulating the T Helper 1 Immune Response After the Coronavac Vaccination</title><author>Hanggara, Dian Sukma ; 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We also observed if these cytokines played any significance in the CoronaVac effectiveness for preventing coronavirus disease 2019 (Covid-19) infection. One hundred ninety-four volunteers were monitored for 8 months upon receiving 2 inactivated SARS-CoV2 vaccination injections (CoronaVac, Sinovac Life Sciences). The rate of confirmed Covid-19 infections was the primary outcome. Six to 7 weeks after the second vaccine injection, and blood samples were obtained to measure the serum vitamin D, IFN-γ, and IL-12 levels. Low vitamin D level was defined if vitamin D level <30 ng/mL. Subjects with low vitamin D had lower IFN-γ and IL-12 levels (P = 0.04 and P = 0.04, respectively). The receiver operating characteristics curve analysis revealed that the area under curve for IFN-γ was 0.59, whereas IL-12 was 0.59 for predicting the low vitamin D levels. During follow-up, a higher incidence of Covid-19 infections was observed in subjects with low IFN-γ levels (P = 0.03). Kaplan–Meier survival analysis revealed that the cumulative hazard of confirmed Covid-19 cases was increased in subjects with low IFN-γ levels (log-rank test, P = 0.03). We concluded that lower vitamin D level was correlated with a lower Th1 immune response, whereas the adequate IFN-γ level was required to obtain better CoronaVac effectiveness.</abstract><cop>New Rochelle</cop><pub>Mary Ann Liebert, Inc</pub><doi>10.1089/jir.2021.0218</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9053-545X</orcidid></addata></record> |
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| ispartof | Journal of interferon & cytokine research, 2022-07, Vol.42 (7), p.329-335 |
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| source | Alma/SFX Local Collection |
| subjects | Calciferol Coronaviruses COVID-19 COVID-19 vaccines Cytokines Deactivation Immune response Immune system Infections Interferon Interleukin 12 Lymphocytes T Rank tests Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Survival analysis Vaccines Viral diseases Vitamin D γ-Interferon |
| title | The Role of Vitamin D for Modulating the T Helper 1 Immune Response After the Coronavac Vaccination |
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