The Role of Vitamin D for Modulating the T Helper 1 Immune Response After the Coronavac Vaccination

The purpose of this study was to observe the role of vitamin D levels with T helper 1 (Th1)-type cytokines, such as interferon γ (IFN-γ) and interleukin-12 (IL-12) efficacy, in those who had already received 2 injections of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vacc...

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Veröffentlicht in:Journal of interferon & cytokine research 2022-07, Vol.42 (7), p.329-335
Hauptverfasser: Hanggara, Dian Sukma, Iskandar, Agustin, Susianti, Hani, Wahono, Cesarius Singgih, Pratama, Mirza Zaka, Nugraha, Aditya Satriya, Wibawa, Purwa Adrianta, Kesuma, Tanti Adelia, Sekarani, Ayu, Handono, Kusworini, Rahman, Perdana Aditya, Anshory, Muhammad
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Sprache:eng
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Zusammenfassung:The purpose of this study was to observe the role of vitamin D levels with T helper 1 (Th1)-type cytokines, such as interferon γ (IFN-γ) and interleukin-12 (IL-12) efficacy, in those who had already received 2 injections of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccines (CoronaVac). We also observed if these cytokines played any significance in the CoronaVac effectiveness for preventing coronavirus disease 2019 (Covid-19) infection. One hundred ninety-four volunteers were monitored for 8 months upon receiving 2 inactivated SARS-CoV2 vaccination injections (CoronaVac, Sinovac Life Sciences). The rate of confirmed Covid-19 infections was the primary outcome. Six to 7 weeks after the second vaccine injection, and blood samples were obtained to measure the serum vitamin D, IFN-γ, and IL-12 levels. Low vitamin D level was defined if vitamin D level
ISSN:1079-9907
1557-7465
DOI:10.1089/jir.2021.0218