Central neuronal transmission in response to tonic cold pain is modulated in people with type 1 diabetes and severe polyneuropathy
This study aimed to investigate cortical source activity and identify source generators in people with type 1 diabetes during rest and tonic cold pain. Forty-eight participants with type 1 diabetes and neuropathy, and 21 healthy controls were investigated with electroencephalography (EEG) during 5-m...
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| Veröffentlicht in: | Journal of diabetes and its complications 2022-08, Vol.36 (8), p.108263-108263, Article 108263 |
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| container_title | Journal of diabetes and its complications |
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| creator | Mark, Esben Bolvig Liao, Donghua Nedergaard, Rasmus Bach Hansen, Tine Maria Drewes, Asbjørn Mohr Brock, Christina |
| description | This study aimed to investigate cortical source activity and identify source generators in people with type 1 diabetes during rest and tonic cold pain.
Forty-eight participants with type 1 diabetes and neuropathy, and 21 healthy controls were investigated with electroencephalography (EEG) during 5-minutes resting and 2-minutes tonic cold pain (immersing the hand into water at 2 °C). EEG power was assessed in eight frequency bands, and EEG source generators were analyzed using standardized low-resolution electromagnetic tomography (sLORETA).
Compared to resting EEG, cold pain EEG power differed in all bands in the diabetes group (all p |
| doi_str_mv | 10.1016/j.jdiacomp.2022.108263 |
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Forty-eight participants with type 1 diabetes and neuropathy, and 21 healthy controls were investigated with electroencephalography (EEG) during 5-minutes resting and 2-minutes tonic cold pain (immersing the hand into water at 2 °C). EEG power was assessed in eight frequency bands, and EEG source generators were analyzed using standardized low-resolution electromagnetic tomography (sLORETA).
Compared to resting EEG, cold pain EEG power differed in all bands in the diabetes group (all p < 0.001) and six bands in the controls (all p < 0.05). Source generator activity in the diabetes group was increased in delta, beta2, beta3, and gamma bands and decreased in alpha1 (all p < 0.006) with changes mainly seen in the frontal and limbic lobe. Compared to controls, people with diabetes had decreased source generator activity during cold pain in the beta2 and beta3 bands (all p < 0.05), mainly in the frontal lobe.
Participants with type 1 diabetes had altered EEG power and source generator activity predominantly in the frontal and limbic lobe during tonic cold pain. The results may indicate modulated central transmission and neuronal impairment.
•Diabetes mellitus may lead to functional alterations in processing of pain.•EEG during experimental pain enables identification of related source generators.•Cold pain in people with diabetes leads to widespread activation of the pain matrix.•Compared to controls, people with diabetes had decreased source generator activity during pain.</description><identifier>ISSN: 1056-8727</identifier><identifier>EISSN: 1873-460X</identifier><identifier>DOI: 10.1016/j.jdiacomp.2022.108263</identifier><language>eng</language><publisher>Philadelphia: Elsevier Inc</publisher><subject>Brain research ; Cold ; Diabetes ; Diabetes mellitus ; Diabetic neuropathy ; Electrodes ; Electroencephalography ; Generators ; Magnetic resonance imaging ; Nervous system ; Neuropathy ; Pain ; Software ; Source localization ; Wavelet transforms</subject><ispartof>Journal of diabetes and its complications, 2022-08, Vol.36 (8), p.108263-108263, Article 108263</ispartof><rights>2022 The Author(s)</rights><rights>2022. The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c368t-e2412c17389711ec8139071228abcd5ceda4916e1283fc097b108bca3a610c373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2697660989?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978,64366,64368,64370,72220</link.rule.ids></links><search><creatorcontrib>Mark, Esben Bolvig</creatorcontrib><creatorcontrib>Liao, Donghua</creatorcontrib><creatorcontrib>Nedergaard, Rasmus Bach</creatorcontrib><creatorcontrib>Hansen, Tine Maria</creatorcontrib><creatorcontrib>Drewes, Asbjørn Mohr</creatorcontrib><creatorcontrib>Brock, Christina</creatorcontrib><title>Central neuronal transmission in response to tonic cold pain is modulated in people with type 1 diabetes and severe polyneuropathy</title><title>Journal of diabetes and its complications</title><description>This study aimed to investigate cortical source activity and identify source generators in people with type 1 diabetes during rest and tonic cold pain.
Forty-eight participants with type 1 diabetes and neuropathy, and 21 healthy controls were investigated with electroencephalography (EEG) during 5-minutes resting and 2-minutes tonic cold pain (immersing the hand into water at 2 °C). EEG power was assessed in eight frequency bands, and EEG source generators were analyzed using standardized low-resolution electromagnetic tomography (sLORETA).
Compared to resting EEG, cold pain EEG power differed in all bands in the diabetes group (all p < 0.001) and six bands in the controls (all p < 0.05). Source generator activity in the diabetes group was increased in delta, beta2, beta3, and gamma bands and decreased in alpha1 (all p < 0.006) with changes mainly seen in the frontal and limbic lobe. Compared to controls, people with diabetes had decreased source generator activity during cold pain in the beta2 and beta3 bands (all p < 0.05), mainly in the frontal lobe.
Participants with type 1 diabetes had altered EEG power and source generator activity predominantly in the frontal and limbic lobe during tonic cold pain. The results may indicate modulated central transmission and neuronal impairment.
•Diabetes mellitus may lead to functional alterations in processing of pain.•EEG during experimental pain enables identification of related source generators.•Cold pain in people with diabetes leads to widespread activation of the pain matrix.•Compared to controls, people with diabetes had decreased source generator activity during pain.</description><subject>Brain research</subject><subject>Cold</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic neuropathy</subject><subject>Electrodes</subject><subject>Electroencephalography</subject><subject>Generators</subject><subject>Magnetic resonance imaging</subject><subject>Nervous system</subject><subject>Neuropathy</subject><subject>Pain</subject><subject>Software</subject><subject>Source localization</subject><subject>Wavelet transforms</subject><issn>1056-8727</issn><issn>1873-460X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1vGyEQhldVIzVN-hcqpF56WYcBG9hbK6sfkSL10kq9IcyOFVZroMCm8jW_POO4vfRSCcEAzwy883bdW-Ar4KBuptU0BufTIa8EF4IOjVDyRXcJRst-rfjPlxTzjeqNFvpV97rWiXOuNhu47B63GFtxM4u4lBQpoF2sh1BrSJGFyArWnGJF1hKNGDzzaR5ZdnQXKjukcZldw_HEZkx5RvY7tHvWjhkZMPraDhtW5uLIKj5gQZbTfHx-L7t2f7zuLvZurvjmz3rV_fj86fv2a3_37cvt9uNd76UyrUexBuFBSzNoAPQG5MA1CGHczo8bj6NbD6AQhJF7zwe9o0bsvJNOAfdSy6vu_bluLunXgrVZUulxnl3EtFQr1EBdApoJffcPOqWlUHeeKa0UH8xAlDpTvqRaC-5tLuHgytECtydr7GT_WmNP1tizNZT44ZyIJPchYLHVB4wkIRT0zY4p_K_EEwJbnEA</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>Mark, Esben Bolvig</creator><creator>Liao, Donghua</creator><creator>Nedergaard, Rasmus Bach</creator><creator>Hansen, Tine Maria</creator><creator>Drewes, Asbjørn Mohr</creator><creator>Brock, Christina</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202208</creationdate><title>Central neuronal transmission in response to tonic cold pain is modulated in people with type 1 diabetes and severe polyneuropathy</title><author>Mark, Esben Bolvig ; Liao, Donghua ; Nedergaard, Rasmus Bach ; Hansen, Tine Maria ; Drewes, Asbjørn Mohr ; Brock, Christina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-e2412c17389711ec8139071228abcd5ceda4916e1283fc097b108bca3a610c373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Brain research</topic><topic>Cold</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic neuropathy</topic><topic>Electrodes</topic><topic>Electroencephalography</topic><topic>Generators</topic><topic>Magnetic resonance imaging</topic><topic>Nervous system</topic><topic>Neuropathy</topic><topic>Pain</topic><topic>Software</topic><topic>Source localization</topic><topic>Wavelet transforms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mark, Esben Bolvig</creatorcontrib><creatorcontrib>Liao, Donghua</creatorcontrib><creatorcontrib>Nedergaard, Rasmus Bach</creatorcontrib><creatorcontrib>Hansen, Tine Maria</creatorcontrib><creatorcontrib>Drewes, Asbjørn Mohr</creatorcontrib><creatorcontrib>Brock, Christina</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of diabetes and its complications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mark, Esben Bolvig</au><au>Liao, Donghua</au><au>Nedergaard, Rasmus Bach</au><au>Hansen, Tine Maria</au><au>Drewes, Asbjørn Mohr</au><au>Brock, Christina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central neuronal transmission in response to tonic cold pain is modulated in people with type 1 diabetes and severe polyneuropathy</atitle><jtitle>Journal of diabetes and its complications</jtitle><date>2022-08</date><risdate>2022</risdate><volume>36</volume><issue>8</issue><spage>108263</spage><epage>108263</epage><pages>108263-108263</pages><artnum>108263</artnum><issn>1056-8727</issn><eissn>1873-460X</eissn><abstract>This study aimed to investigate cortical source activity and identify source generators in people with type 1 diabetes during rest and tonic cold pain.
Forty-eight participants with type 1 diabetes and neuropathy, and 21 healthy controls were investigated with electroencephalography (EEG) during 5-minutes resting and 2-minutes tonic cold pain (immersing the hand into water at 2 °C). EEG power was assessed in eight frequency bands, and EEG source generators were analyzed using standardized low-resolution electromagnetic tomography (sLORETA).
Compared to resting EEG, cold pain EEG power differed in all bands in the diabetes group (all p < 0.001) and six bands in the controls (all p < 0.05). Source generator activity in the diabetes group was increased in delta, beta2, beta3, and gamma bands and decreased in alpha1 (all p < 0.006) with changes mainly seen in the frontal and limbic lobe. Compared to controls, people with diabetes had decreased source generator activity during cold pain in the beta2 and beta3 bands (all p < 0.05), mainly in the frontal lobe.
Participants with type 1 diabetes had altered EEG power and source generator activity predominantly in the frontal and limbic lobe during tonic cold pain. The results may indicate modulated central transmission and neuronal impairment.
•Diabetes mellitus may lead to functional alterations in processing of pain.•EEG during experimental pain enables identification of related source generators.•Cold pain in people with diabetes leads to widespread activation of the pain matrix.•Compared to controls, people with diabetes had decreased source generator activity during pain.</abstract><cop>Philadelphia</cop><pub>Elsevier Inc</pub><doi>10.1016/j.jdiacomp.2022.108263</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Brain research Cold Diabetes Diabetes mellitus Diabetic neuropathy Electrodes Electroencephalography Generators Magnetic resonance imaging Nervous system Neuropathy Pain Software Source localization Wavelet transforms |
| title | Central neuronal transmission in response to tonic cold pain is modulated in people with type 1 diabetes and severe polyneuropathy |
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