Central neuronal transmission in response to tonic cold pain is modulated in people with type 1 diabetes and severe polyneuropathy

Central neuronal transmission in response to tonic cold pain is modulated in people with type 1 diabetes and severe polyneuropathy

This study aimed to investigate cortical source activity and identify source generators in people with type 1 diabetes during rest and tonic cold pain. Forty-eight participants with type 1 diabetes and neuropathy, and 21 healthy controls were investigated with electroencephalography (EEG) during 5-m...

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Veröffentlicht in:Journal of diabetes and its complications 2022-08, Vol.36 (8), p.108263-108263, Article 108263
Hauptverfasser: Mark, Esben Bolvig, Liao, Donghua, Nedergaard, Rasmus Bach, Hansen, Tine Maria, Drewes, Asbjørn Mohr, Brock, Christina
Format: Artikel
Sprache:eng
Schlagworte:
Brain research
Cold
Diabetes
Diabetes mellitus
Diabetic neuropathy
Electrodes
Electroencephalography
Generators
Magnetic resonance imaging
Nervous system
Neuropathy
Pain
Software
Source localization
Wavelet transforms
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Beschreibung
Zusammenfassung:This study aimed to investigate cortical source activity and identify source generators in people with type 1 diabetes during rest and tonic cold pain. Forty-eight participants with type 1 diabetes and neuropathy, and 21 healthy controls were investigated with electroencephalography (EEG) during 5-minutes resting and 2-minutes tonic cold pain (immersing the hand into water at 2 °C). EEG power was assessed in eight frequency bands, and EEG source generators were analyzed using standardized low-resolution electromagnetic tomography (sLORETA). Compared to resting EEG, cold pain EEG power differed in all bands in the diabetes group (all p 
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2022.108263