Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition

Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition

Inhibitors of proximal and terminal complement cascades can often control red-cell hemolysis associated with paroxysmal nocturnal hemoglobinuria, but some patients have breakthrough hemolysis.

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Bibliographische Detailangaben
Veröffentlicht in:The New England journal of medicine 2022-07, Vol.387 (2), p.160-166
Hauptverfasser: Notaro, Rosario, Luzzatto, Lucio
Format: Artikel
Sprache:eng
Schlagworte:
Allergy
Anemia
Autoimmune Disease
Autoimmune diseases
Bone marrow
Clinical trials
Cloning
Coagulation
Enzymes
Hematology
Hemoglobin
Hemolysis
Immunology
Infections
Oncology
Oncology General
Paroxysmal nocturnal hemoglobinuria
Pharmacodynamics
Proteins
Thrombosis
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Beschreibung
Zusammenfassung:Inhibitors of proximal and terminal complement cascades can often control red-cell hemolysis associated with paroxysmal nocturnal hemoglobinuria, but some patients have breakthrough hemolysis.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMra2201664