A dual-targeting peptide facilitates targeting anti-inflammation to attenuate atherosclerosis in ApoE mice

A dual-targeting peptide facilitates targeting anti-inflammation to attenuate atherosclerosis in ApoE mice

We report a peptidic dual-targeting drug delivery platform (integrins targeting and self-assembly instructed by matrix metalloproteinases) towards inflamed endothelial cells, which improved the anti-inflammatory ability of the loaded drug ( i.e. , puerarin) in vitro and thus improved the antiatherog...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-08, Vol.58 (62), p.869-8693
Hauptverfasser: Wu, Bo, Zhong, Yuanzhi, Chen, Jinmin, Pan, Xianmei, Fan, Xianglin, Chen, Peier, Fu, Chenxing, Ou, Caiwen, Chen, Minsheng
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Sprache:eng
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Atherosclerosis
Endothelial cells
Matrix metalloproteinases
Self-assembly
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container_end_page 8693
container_issue 62
container_start_page 869
container_title Chemical communications (Cambridge, England)
container_volume 58
creator Wu, Bo
Zhong, Yuanzhi
Chen, Jinmin
Pan, Xianmei
Fan, Xianglin
Chen, Peier
Fu, Chenxing
Ou, Caiwen
Chen, Minsheng
description We report a peptidic dual-targeting drug delivery platform (integrins targeting and self-assembly instructed by matrix metalloproteinases) towards inflamed endothelial cells, which improved the anti-inflammatory ability of the loaded drug ( i.e. , puerarin) in vitro and thus improved the antiatherogenic effect of the loaded drug ( i.e. , puerarin) in vivo . A dual-targeting peptide towards inflamed endothelial cells is reported, which improves the antiatherogenic effect of anti-inflammatory drug puerarin.
doi_str_mv 10.1039/d2cc01457b
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Atherosclerosis
Endothelial cells
Matrix metalloproteinases
Self-assembly
title A dual-targeting peptide facilitates targeting anti-inflammation to attenuate atherosclerosis in ApoE mice
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