A dual-targeting peptide facilitates targeting anti-inflammation to attenuate atherosclerosis in ApoE mice

We report a peptidic dual-targeting drug delivery platform (integrins targeting and self-assembly instructed by matrix metalloproteinases) towards inflamed endothelial cells, which improved the anti-inflammatory ability of the loaded drug ( i.e. , puerarin) in vitro and thus improved the antiatherogenic effect of the loaded drug ( i.e. , puerarin) in vivo . A dual-targeting peptide towards inflamed endothelial cells is reported, which improves the antiatherogenic effect of anti-inflammatory drug puerarin.