Preparation of spherical monodisperse ferrimagnetic iron-oxide microparticles between 1 and 5 μm diameter

Preparation of spherical monodisperse ferrimagnetic iron-oxide microparticles between 1 and 5 μm diameter

The production of spherical monodisperse iron-oxide microparticles in the size range between 0.8 and 5 μm is described. The particles can be ferrimagnetic (Fe 3O 4) or non-magnetic (α-Fe 2O 3). The particles were radiolabeled with 99mTc or 111In, and the leakage of the radiolabel within 24 h was 0.1...

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Veröffentlicht in:Journal of magnetism and magnetic materials 2001, Vol.225 (1), p.8-16
Hauptverfasser: Möller, Winfried, Scheuch, Gerhard, Sommerer, Knut, Heyder, Joachim
Format: Artikel
Sprache:eng
Schlagworte:
Alveolar clearance
Cell motility
Chemistry
Colloidal state and disperse state
Exact sciences and technology
Ferrimagnetic
General and physical chemistry
General, apparatus, technics of preparation
Indium-111 (In-111)
Iron-oxide particles
Lung imaging
Magnetite
Monodisperse
Nebulization
Preparation
Radiolabeling
Spherical
Spinning top aerosol generator
Technetium-99 m (Tc-99 m)
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Zusammenfassung:The production of spherical monodisperse iron-oxide microparticles in the size range between 0.8 and 5 μm is described. The particles can be ferrimagnetic (Fe 3O 4) or non-magnetic (α-Fe 2O 3). The particles were radiolabeled with 99mTc or 111In, and the leakage of the radiolabel within 24 h was 0.1% in the human lung. The particles can be used to study the motility and the integrity of living cells.
ISSN:0304-8853
DOI:10.1016/S0304-8853(00)01221-X