Alterations in bone marrow microRNA expression profiles on infection with avian pathogenic Escherichia coli

Alterations in bone marrow microRNA expression profiles on infection with avian pathogenic Escherichia coli

Avian pathogenic Escherichia coli (APEC) is one of the most common avian bacterial diseases globally. The bone marrow is a reservoir of immature immune cells. To elucidate the role of bone marrow microRNAs (miRNAs) in regulating the host response to APEC infection, we performed miRNA-seq to investig...

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Veröffentlicht in:Research in veterinary science 2022-12, Vol.150, p.1-9
Hauptverfasser: Yin, Lei, Shen, Xuehuai, Zhang, Danjun, Zhao, Ruihong, Hou, Hongyan, Hu, Xiaomiao, Wang, Jieru, Dai, Yin, Pan, Xiaocheng, Qi, Kezong
Format: Artikel
Sprache:eng
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Avian pathogenic Escherichia coli
Bacterial diseases
Bone marrow
Chickens
Chromosome 5
Cyclic GMP
Cytokines
E coli
Escherichia coli
Gene regulation
Genes
Immune response
Immune system
Infections
Kinases
Laboratory animals
MAP kinase
microRNA
MicroRNAs
miRNA
Pathogens
Poultry
Regulation
Reverse transcription
Ribonucleic acid
RNA
Specific pathogen free
Statistical analysis
Transcriptomes
Veterinary medicine
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Zusammenfassung:Avian pathogenic Escherichia coli (APEC) is one of the most common avian bacterial diseases globally. The bone marrow is a reservoir of immature immune cells. To elucidate the role of bone marrow microRNAs (miRNAs) in regulating the host response to APEC infection, we performed miRNA-seq to investigate alterations in the expression of bone marrow miRNAs in three groups of specific pathogen-free chickens: non-challenged (NC) and challenged with APEC for 12 h (C12) and 24 h (C24). Twenty and 19 differentially expressed miRNAs (fold change >2, P 
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2022.06.023