Hydrogen bonding-enabled gold catalysis: ligand effects in gold-catalyzed cycloisomerizations in hexafluoroisopropanol (HFIP)

Hydrogen bonding-enabled gold catalysis: ligand effects in gold-catalyzed cycloisomerizations in hexafluoroisopropanol (HFIP)

Gold catalysis has witnessed immense evolution in recent years, yet it still requires the use of activators to render the common [AuCl(L)] complexes catalytically active. Herein, the H-bonding donor properties of hexafluoroisopropanol (HFIP) are utilized for AuCl bond activation and the ancillary li...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-07, Vol.58 (61), p.8516-8519
Hauptverfasser: Tzouras, Nikolaos V, Gobbo, Alberto, Pozsoni, Nestor Bracho, Chalkidis, Savvas G, Bhandary, Subhrajyoti, Van Hecke, Kristof, Vougioukalakis, Georgios C, Nolan, Steven P
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Gold
Hydrogen bonding
Isomerization
Ligands
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Beschreibung
Zusammenfassung:Gold catalysis has witnessed immense evolution in recent years, yet it still requires the use of activators to render the common [AuCl(L)] complexes catalytically active. Herein, the H-bonding donor properties of hexafluoroisopropanol (HFIP) are utilized for AuCl bond activation and the ancillary ligand and counteranion effects on cycloisomerization reactions are showcased in HFIP as solvent. Hexafluoroisopropanol (HFIP) serves as a versatile solvent for activator-free, [AuCl(L)] catalysis.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc03056j