Autoimmune gastritis: long-term natural history in naïve Helicobacter pylori-negative patients

ObjectiveAutoimmune gastritis (AIG) is an immunomediated disease targeting parietal cells, eventually resulting in oxyntic-restricted atrophy. This long-term follow-up study aimed at elucidating the natural history, histological phenotype(s), and associated cancer risk of patients with AIG consisten...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Gut 2023-01, Vol.72 (1), p.30-38
Hauptverfasser:	Rugge, Massimo, Bricca, Ludovica, Guzzinati, Stefano, Sacchi, Diana, Pizzi, Marco, Savarino, Edoardo, Farinati, Fabio, Zorzi, Manuel, Fassan, Matteo, Dei Tos, Angelo Paolo, Malfertheiner, Peter, Genta, Robert M, Graham, David Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Atrophy Atrophy - complications autoimmune disease Biopsy Comorbidity Dysplasia Follow-Up Studies Gastric cancer gastric metaplasia Gastritis Gastritis - pathology Gastritis, Atrophic - epidemiology Helicobacter Infections - complications Helicobacter Infections - pathology Helicobacter pylori Histology Humans Hyperplasia Immune system Infections Inflammation Inflammation - complications Malignancy Metaplasia Molecular biology Natural history Neuroendocrine tumors Parietal cells Phenotypes Precancerous Conditions - pathology Serology staging Stomach Stomach Neoplasms - complications Thyroid cancer
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	ObjectiveAutoimmune gastritis (AIG) is an immunomediated disease targeting parietal cells, eventually resulting in oxyntic-restricted atrophy. This long-term follow-up study aimed at elucidating the natural history, histological phenotype(s), and associated cancer risk of patients with AIG consistently tested H. pylori-negative (naïve H. pylori-negative subjects).DesignTwo-hundred eleven naïve H. pylori-negative patients (tested by serology, histology, molecular biology) with AIG (F:M=3.15:1; p
ISSN:	0017-5749 1468-3288 1468-3288
DOI:	10.1136/gutjnl-2022-327827