Interaction effect of blood glucose and pressure on the risk of chronic kidney disease: a population-based prospective cohort study

Objective To evaluate the interaction effect of blood glucose and blood pressure on the risk of chronic kidney disease (CKD). Methods 31,165 subjects were selected without CKD at baseline and had completed the first follow-up from “Jinchang cohort”. Cox regression model and restricted cubic splines functions were used to evaluate the effects of blood glucose or pressure on the incidence of CKD and dose-response relationship after adjusting for confounding covariates. Synergic effect was assessed by the multiplicative or additive interaction scale. Results Among 31,165 subjects, 1307 new-onset CKD were observed during 68905.78 person-years follow-up, and the incidence density was 18.97 per 1000 person-years. The risk of CKD gradually increased with the increase of blood pressure in diabetes, pre-diabetes and normal groups ( P trend