Biodegradable polyaspartamide‐g‐C18/DOPA/GLY‐NEO nano‐adhesives for wound closure/healing with antimicrobial activity

This study was focused on the development of biodegradable nano‐adhesives with efficient sealing and antibiotic effects for wound healing. Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles—octadecylamine (C18) for nano‐aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection. Specifically, NEO was conjugated to PASPAM with a pH‐sensitive glycine (GLY) linker for targeted delivery on the acidic wound site. About 60% of the drug was ramteleased at pH 6.0, while about 22% was released at pH 7.4, showing the faster drug release pattern of nano‐adhesives in the acidic environment. The C18/DOPA/GLY‐NEO‐g‐PASPAM nano‐adhesives showed the bacterial viability higher than 70% at pH 7.4, but about 40% at pH 6.0. The wound breaking strength of the polymer‐treated skin was much higher than that of the bare skin. According to the in vivo wound healing test using a mouse model, C18/DOPA/GLY‐NEO‐g‐PASPAM nano‐adhesives showed much faster healing performance than sutures. From those results, C18/DOPA/GLY‐NEO‐g‐PASPAM nano‐adhesives are expected to be utilized as effective adhesives that promote the wound healing with inhibition of bacterial infection. The development of biodegradable nano‐adhesives for wound healing with the efficient sealing and antifungal effects is focused in this study. C18/DOPA/GLY‐NEO‐g‐PASPAM nano‐adhesives demonstrate efficient sealing and antifungal effects for wound healing. C18/DOPA/GLY‐NEO‐g‐PASPAM nano‐aggregate system releases about 60% of the loaded drug at pH 6.0. C18/DOPA/GLY‐NEO‐g‐PASPAM system shows excellent adhesion at in vivo wound healing test using a mouse model.