Triglyceride-glucose index impact on in-hospital mortality in acute myocardial infarction. Results from the RECUIMA multicenter registry

INTRODUCTIONThe triglyceride-glucose (TyG) index is considered a new marker of insulin resistance, and is associated with the development of cardiovascular diseases. OBJECTIVETo evaluate the capability of TyG index to predict in-hospital -mortality in patients with acute ST-elevation myocardial infarction. METHODSMulticenter cohort study that enrolled 1123 patients included in the Cuban Registry of Acute Myocardial Infarction between January 2018 and June 2021. RESULTSTyG index optimal cutoff point to predict mortality was 8.96 (sensitivity, 65.2%; specificity, 62.0%; area under the curve; 0.636; p < 0.001). In-hospital mortality was significantly higher in the group with TyG index ≥ 8.96. The logistic regression analysis revealed that the TyG index was an independent mortality predictor (OR = 2.959; 95% CI = 1.457-6.010; p = 0.003). When the TyG index was included in the multivariate model, it increased its predictive capacity (area under the curve, 0.917, p < 0.001). Kaplan-Meier curves showed significant differences between patient groups (p < 0.001). CONCLUSIONSThe TyG index constitutes an independent risk factor of in-hospital mortality in patients with acute ST-elevation myocardial infarction.