The Potency of a KRAS Silent Variant

The Potency of a KRAS Silent Variant

The overrepresentation of a silent variant in KRAS led investigators to explore whether this mutation was biologically relevant (it was) and could be exploited in a mouse model to treat KRAS-mutant cancer.

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Bibliographische Detailangaben
Veröffentlicht in:The New England journal of medicine 2022-06, Vol.386 (26), p.2523-2525
Hauptverfasser: Molina-Arcas, Miriam, Downward, Julian
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Genetics
Genetics General
Hematology
K-Ras protein
Kinases
Lung cancer
Mutation
Oncology
Oncology General
Proteins
Treatments in Oncology
Tumors
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Beschreibung
Zusammenfassung:The overrepresentation of a silent variant in KRAS led investigators to explore whether this mutation was biologically relevant (it was) and could be exploited in a mouse model to treat KRAS-mutant cancer.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMcibr2202981