Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma

A total of 12 pediatric patients with diffuse intrinsic pontine glioma were treated with a direct infusion of an oncolytic virus, followed by radiotherapy. The tumor size was reduced in 9 patients, and disease was stable over a median follow-up of 18 months in 8 patients.

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Veröffentlicht in:	The New England journal of medicine 2022-06, Vol.386 (26), p.2471-2481
Hauptverfasser:	Gállego Pérez-Larraya, Jaime, Garcia-Moure, Marc, Labiano, Sara, Patiño-García, Ana, Dobbs, Jessica, Gonzalez-Huarriz, Marisol, Zalacain, Marta, Marrodan, Lucia, Martinez-Velez, Naiara, Puigdelloses, Montserrat, Laspidea, Virginia, Astigarraga, Itziar, Lopez-Ibor, Blanca, Cruz, Ofelia, Oscoz Lizarbe, Miren, Hervas-Stubbs, Sandra, Alkorta-Aranburu, Gorka, Tamayo, Ibon, Tavira, Beatriz, Hernandez-Alcoceba, Ruben, Jones, Chris, Dharmadhikari, Gitanjali, Ruiz-Moreno, Cristian, Stunnenberg, Henk, Hulleman, Esther, van der Lugt, Jasper, Idoate, Miguel Á., Diez-Valle, Ricardo, Esparragosa Vázquez, Inés, Villalba, Maria, de Andrea, Carlos, Núñez-Córdoba, Jorge M., Ewald, Brett, Robbins, Joan, Fueyo, Juan, Gomez-Manzano, Candelaria, Lang, Frederick F., Tejada, Sonia, Alonso, Marta M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adolescent Adverse events Antitumor activity Astrocytoma - radiotherapy Astrocytoma - therapy Autopsy Biopsy Blood tests Brain cancer Brain Stem Neoplasms - mortality Brain Stem Neoplasms - pathology Brain Stem Neoplasms - radiotherapy Brain Stem Neoplasms - therapy Brain Tumor Brain tumors Cerebellum Child Child, Preschool Childhood Cancer Childhood Diseases Diffuse Intrinsic Pontine Glioma - mortality Diffuse Intrinsic Pontine Glioma - radiotherapy Diffuse Intrinsic Pontine Glioma - therapy Glioma Glioma - radiotherapy Glioma - therapy Hematology Humans Immune response Infectious Disease Infusions, Intralesional Lymphocytes T Magnetic resonance imaging Medical prognosis Nausea Neuroimaging Neurology Neurosurgery Oncology Oncolysis Oncolytic Virotherapy - adverse effects Oncolytic Virotherapy - methods Oncolytic Viruses Paresis Patients Pediatrics Pediatrics General Peripheral blood Quality of Life Radiation therapy Treatments in Oncology Tumor cells Tumor Microenvironment Viral Infections Viruses Vomiting
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Beschreibung
Zusammenfassung:	A total of 12 pediatric patients with diffuse intrinsic pontine glioma were treated with a direct infusion of an oncolytic virus, followed by radiotherapy. The tumor size was reduced in 9 patients, and disease was stable over a median follow-up of 18 months in 8 patients.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2202028