Correlation between IgAC3 ratio and oxford score in IgA nephropathy
Background Complement activation has an important role in the pathogenesis of IgA nephropathy. Objective To determine the correlation between IgAC3 ratio (IgA/C3) and total Oxford score and predictive value of IgA/C3 in IgA nephropathy. Methods Forty-three patients diagnosed with IgA nephropathy wit...
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| Veröffentlicht in: | Clinical and experimental nephrology 2022-10, Vol.26 (10), p.982-987 |
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| container_title | Clinical and experimental nephrology |
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| creator | Karahisar Şirali, Semahat Büberci, Refika |
| description | Background
Complement activation has an important role in the pathogenesis of IgA nephropathy.
Objective
To determine the correlation between IgAC3 ratio (IgA/C3) and total Oxford score and predictive value of IgA/C3 in IgA nephropathy.
Methods
Forty-three patients diagnosed with IgA nephropathy with > 10 glomerular + 1 arteries in biopsy were included in the study. Hematological and biochemical variables of the blood sample taken before the biopsy and total Oxford score were recorded. The study group was divided into two groups as proteinuria ≥ 1 g (PU ≥ 1) and proteinuria |
| doi_str_mv | 10.1007/s10157-022-02244-7 |
| format | Article |
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Complement activation has an important role in the pathogenesis of IgA nephropathy.
Objective
To determine the correlation between IgAC3 ratio (IgA/C3) and total Oxford score and predictive value of IgA/C3 in IgA nephropathy.
Methods
Forty-three patients diagnosed with IgA nephropathy with > 10 glomerular + 1 arteries in biopsy were included in the study. Hematological and biochemical variables of the blood sample taken before the biopsy and total Oxford score were recorded. The study group was divided into two groups as proteinuria ≥ 1 g (PU ≥ 1) and proteinuria < 1 g (PU < 1). Statistics were carried out with SPSS 22.0 program.
p
< .05 considered as significant.
Results
The mean age of 43 patients was 40.4 (± 11.9) years; 51.2% of them were women. Proteinuria as 1 g or more was in 27 of 43 patients, and less than 1 g in 16 patients. The serum C3 level was lower in the group with PU ≥ 1 and showed a significant positive correlation with the IgA/C3 total Oxford score.
Conclusion
A significant correlation was found between serum IgA/C3 and total Oxford score.</description><identifier>ISSN: 1342-1751</identifier><identifier>EISSN: 1437-7799</identifier><identifier>DOI: 10.1007/s10157-022-02244-7</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Arteries ; Biopsy ; Complement activation ; IgA nephropathy ; Immunoglobulin A ; Medicine ; Medicine & Public Health ; Nephrology ; Original Article ; Proteinuria ; Urology</subject><ispartof>Clinical and experimental nephrology, 2022-10, Vol.26 (10), p.982-987</ispartof><rights>The Author(s), under exclusive licence to The Japanese Society of Nephrology 2022</rights><rights>The Author(s), under exclusive licence to The Japanese Society of Nephrology 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-3844c7d0443470236f3d2b697edc5b32a8359d9b716b2e1fa3c37fc342649743</citedby><cites>FETCH-LOGICAL-c361t-3844c7d0443470236f3d2b697edc5b32a8359d9b716b2e1fa3c37fc342649743</cites><orcidid>0000-0003-0981-8928</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10157-022-02244-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10157-022-02244-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Karahisar Şirali, Semahat</creatorcontrib><creatorcontrib>Büberci, Refika</creatorcontrib><title>Correlation between IgAC3 ratio and oxford score in IgA nephropathy</title><title>Clinical and experimental nephrology</title><addtitle>Clin Exp Nephrol</addtitle><description>Background
Complement activation has an important role in the pathogenesis of IgA nephropathy.
Objective
To determine the correlation between IgAC3 ratio (IgA/C3) and total Oxford score and predictive value of IgA/C3 in IgA nephropathy.
Methods
Forty-three patients diagnosed with IgA nephropathy with > 10 glomerular + 1 arteries in biopsy were included in the study. Hematological and biochemical variables of the blood sample taken before the biopsy and total Oxford score were recorded. The study group was divided into two groups as proteinuria ≥ 1 g (PU ≥ 1) and proteinuria < 1 g (PU < 1). Statistics were carried out with SPSS 22.0 program.
p
< .05 considered as significant.
Results
The mean age of 43 patients was 40.4 (± 11.9) years; 51.2% of them were women. Proteinuria as 1 g or more was in 27 of 43 patients, and less than 1 g in 16 patients. The serum C3 level was lower in the group with PU ≥ 1 and showed a significant positive correlation with the IgA/C3 total Oxford score.
Conclusion
A significant correlation was found between serum IgA/C3 and total Oxford score.</description><subject>Arteries</subject><subject>Biopsy</subject><subject>Complement activation</subject><subject>IgA nephropathy</subject><subject>Immunoglobulin A</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Proteinuria</subject><subject>Urology</subject><issn>1342-1751</issn><issn>1437-7799</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kE9LxDAQxYMouK5-AU8BL16qSSZtmuNS_LOw4GXvIU3T3S7dpCZddL-9WSsIHjwMM8z83vB4CN1S8kAJEY-REpqLjDB2Ks4zcYZmlIPIhJDyPM3AWUZFTi_RVYw7QkgpczlDVeVDsL0eO-9wbccPax1ebhYV4HBaYu0a7D9bHxocjQ8Wd9937OywDX7Q4_Z4jS5a3Ud789PnaP38tK5es9Xby7JarDIDBR0zKDk3oiGcAxeEQdFCw-pCCtuYvAamS8hlI2tBi5pZ2mowIFqTjBdcCg5zdD-9HYJ_P9g4qn0Xje177aw_RMWKkhKQsqQJvfuD7vwhuGROsVISkvzkeaLYRJngYwy2VUPo9jocFSXqFKuaYlUpUvUdqxJJBJMoJthtbPh9_Y_qCxaNd-k</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Karahisar Şirali, Semahat</creator><creator>Büberci, Refika</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0981-8928</orcidid></search><sort><creationdate>20221001</creationdate><title>Correlation between IgAC3 ratio and oxford score in IgA nephropathy</title><author>Karahisar Şirali, Semahat ; Büberci, Refika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-3844c7d0443470236f3d2b697edc5b32a8359d9b716b2e1fa3c37fc342649743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arteries</topic><topic>Biopsy</topic><topic>Complement activation</topic><topic>IgA nephropathy</topic><topic>Immunoglobulin A</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Proteinuria</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karahisar Şirali, Semahat</creatorcontrib><creatorcontrib>Büberci, Refika</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karahisar Şirali, Semahat</au><au>Büberci, Refika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between IgAC3 ratio and oxford score in IgA nephropathy</atitle><jtitle>Clinical and experimental nephrology</jtitle><stitle>Clin Exp Nephrol</stitle><date>2022-10-01</date><risdate>2022</risdate><volume>26</volume><issue>10</issue><spage>982</spage><epage>987</epage><pages>982-987</pages><issn>1342-1751</issn><eissn>1437-7799</eissn><abstract>Background
Complement activation has an important role in the pathogenesis of IgA nephropathy.
Objective
To determine the correlation between IgAC3 ratio (IgA/C3) and total Oxford score and predictive value of IgA/C3 in IgA nephropathy.
Methods
Forty-three patients diagnosed with IgA nephropathy with > 10 glomerular + 1 arteries in biopsy were included in the study. Hematological and biochemical variables of the blood sample taken before the biopsy and total Oxford score were recorded. The study group was divided into two groups as proteinuria ≥ 1 g (PU ≥ 1) and proteinuria < 1 g (PU < 1). Statistics were carried out with SPSS 22.0 program.
p
< .05 considered as significant.
Results
The mean age of 43 patients was 40.4 (± 11.9) years; 51.2% of them were women. Proteinuria as 1 g or more was in 27 of 43 patients, and less than 1 g in 16 patients. The serum C3 level was lower in the group with PU ≥ 1 and showed a significant positive correlation with the IgA/C3 total Oxford score.
Conclusion
A significant correlation was found between serum IgA/C3 and total Oxford score.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><doi>10.1007/s10157-022-02244-7</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0981-8928</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1342-1751 |
| ispartof | Clinical and experimental nephrology, 2022-10, Vol.26 (10), p.982-987 |
| issn | 1342-1751 1437-7799 |
| language | eng |
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| source | SpringerNature Journals |
| subjects | Arteries Biopsy Complement activation IgA nephropathy Immunoglobulin A Medicine Medicine & Public Health Nephrology Original Article Proteinuria Urology |
| title | Correlation between IgAC3 ratio and oxford score in IgA nephropathy |
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