Effects of a ketogenic diet in women with PCOS with different uric acid concentrations: a prospective cohort study

•A ketogenic diet intervention is beneficial for overweight/obese women with PCOS•Uric acid concentrations may affect weight loss during ketogenic diet interventions•With weight loss, some women with PCOS can resume menstruation Do overweight/obese women with PCOS with different uric acid concentrations show different effects after a ketogenic diet intervention? The study involved women with PCOS with a body mass index (BMI) of ≥24 kg/m2. Groups showing different uric acid concentrations were given ketogenic diet guidance for 12 weeks. Weight, BMI, body fat percentage, fasting blood glucose, triacylglyerols, total cholesterol, uric acid and other metabolism-related indexes were measured. After 12 weeks of the ketogenic diet intervention, body weight (hyperuricaemia group: P=0.001; non-hyperuricaemia group: P