Nickel-Catalyzed Tandem Ueno–Stork Cyclization: Stereoselective 1,2-Dicarbofunctionalization of Cyclic Alkenes

Nickel-Catalyzed Tandem Ueno–Stork Cyclization: Stereoselective 1,2-Dicarbofunctionalization of Cyclic Alkenes

A nickel-catalyzed tandem Ueno–Stork cyclization is developed to enable stereoselective 1,2-dicarbofunctionalization of cyclic alkenes and efficiently build various bicyclic products. This new protocol does not involve any toxic or difficult-to-remove tin reagent and is scalable and amenable to buil...

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Veröffentlicht in:Journal of organic chemistry 2022-07, Vol.87 (13), p.8796-8801
Hauptverfasser: de Andrade Horn, Pedro, Sims, Hunter S., Dai, Mingji
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes
Catalysis
Cyclization
Cycloparaffins
Nickel
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Zusammenfassung:A nickel-catalyzed tandem Ueno–Stork cyclization is developed to enable stereoselective 1,2-dicarbofunctionalization of cyclic alkenes and efficiently build various bicyclic products. This new protocol does not involve any toxic or difficult-to-remove tin reagent and is scalable and amenable to build all-carbon quaternary centers.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.2c00770