The overall process of metastasis: From initiation to a new tumor

Metastasis—a process that involves the migration of cells from the primary site to distant organs—is the leading cause of cancer-associated death. Improved technology and in-depth research on tumors have furthered our understanding of the various mechanisms involved in tumor metastasis. Metastasis is initiated by cancer cells of a specific phenotype, which migrate with the assistance of extracellular components and metastatic traits conferred via epigenetic regulation while modifying their behavior in response to the complex and dynamic human internal environment. In this review, we have summarized the general steps involved in tumor metastasis and their characteristics, incorporating recent studies and topical issues, including epithelial-mesenchymal transition, cancer stem cells, neutrophil extracellular traps, pre-metastatic niche, extracellular vesicles, and dormancy. Several feasible treatment directions have also been summarized. In addition, the correlation between cancer metastasis and lifestyle factors, such as obesity and circadian rhythm, has been illustrated. [Display omitted] •EMT and microenvironment components are key factors in tumor invasion.•Platelets, NETs, and metabolic regulation support intravascular survival of CTCs.•Primary tumor-induced PMNs determine organ tropism and colonization.•Therapies targeting CSCs, CTCs, PMNs, and dormancy may improve poor prognosis.•Circadian rhythm disorder and obesity closely linked to metastasis.