Reduction of SLC7A11 and GPX4 Contributing to Ferroptosis in Sperm from Asthenozoospermia Individuals

Ferroptosis is a newly defined form of regulated cell death, which is involved in various pathophysiological conditions. However, the role of ferroptosis in male infertility remains unclear. In this study, 42 asthenozoospermic and 45 normozoospermic individuals participated. To investigate the ferro...

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Veröffentlicht in:	Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2023, Vol.30 (1), p.247-257
Hauptverfasser:	Hao, Xiaoling, Wang, Hong, Cui, Fang, Yang, Zihan, Ye, Liu, Huang, Run, Meng, Jiangping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System y+ - genetics Asthenozoospermia - genetics Embryology Ferroptosis Humans Infertility, Male - genetics Male Male Reproduction: Original Article Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Phospholipid Hydroperoxide Glutathione Peroxidase - genetics Reactive Oxygen Species - metabolism Reproductive Medicine Semen - metabolism Spermatozoa - metabolism
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Zusammenfassung:	Ferroptosis is a newly defined form of regulated cell death, which is involved in various pathophysiological conditions. However, the role of ferroptosis in male infertility remains unclear. In this study, 42 asthenozoospermic and 45 normozoospermic individuals participated. To investigate the ferroptosis level in the two groups, the levels of reactive oxygen species (ROS), malondialdehyde (MDA), and iron were measured, and mitochondrial membrane potential (MMP) was detected as an indicator of mitochondrial injuries. Compared with the normozoospermic group, ROS ( p
ISSN:	1933-7191 1933-7205
DOI:	10.1007/s43032-022-01004-y