Monoterpenoid Quinoline Alkaloids from Stems and Leaves of Melodinus tenuicaudatus
Two previously undescribed monoterpenoid quinoline alkaloids, namely melotenucadines A and B, together with four known analogs, were characterized from the stems and leaves of Melodinus tenuicaudatus. The structures of the new compounds were established by extensive MS and NMR spectroscopic methods,...
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| Veröffentlicht in: | Chemistry & biodiversity 2022-07, Vol.19 (7), p.e202200209-n/a |
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| creator | Wu, Feng Chen, Yi Yin, Jie‐Lin Zhu, Cun‐Hui Zhang, Yan Liu, Ji‐Kai He, Juan |
| description | Two previously undescribed monoterpenoid quinoline alkaloids, namely melotenucadines A and B, together with four known analogs, were characterized from the stems and leaves of Melodinus tenuicaudatus. The structures of the new compounds were established by extensive MS and NMR spectroscopic methods, while the absolute configuration was conducted by ECD calculations. Melotenucadine B was found to show certain cytotoxicity to MCF‐7 cell (IC50=27.3 μM). |
| doi_str_mv | 10.1002/cbdv.202200209 |
| format | Article |
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The structures of the new compounds were established by extensive MS and NMR spectroscopic methods, while the absolute configuration was conducted by ECD calculations. Melotenucadine B was found to show certain cytotoxicity to MCF‐7 cell (IC50=27.3 μM).</description><identifier>ISSN: 1612-1872</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.202200209</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Absolute configuration ; Alkaloids ; Cytotoxicity ; Leaves ; Melodinus tenuicaudatus ; melotenucadines A and B ; monoterpenoid quinoline alkaloids ; NMR ; Nuclear magnetic resonance ; Quinoline ; Toxicity</subject><ispartof>Chemistry & biodiversity, 2022-07, Vol.19 (7), p.e202200209-n/a</ispartof><rights>2022 Wiley‐VHCA AG, Zurich, Switzerland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3509-69e6e5f7731e4be57c38bf5031859db46734734a8061fad046147761c2b22c133</citedby><cites>FETCH-LOGICAL-c3509-69e6e5f7731e4be57c38bf5031859db46734734a8061fad046147761c2b22c133</cites><orcidid>0000-0002-6682-5481</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.202200209$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.202200209$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Wu, Feng</creatorcontrib><creatorcontrib>Chen, Yi</creatorcontrib><creatorcontrib>Yin, Jie‐Lin</creatorcontrib><creatorcontrib>Zhu, Cun‐Hui</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Liu, Ji‐Kai</creatorcontrib><creatorcontrib>He, Juan</creatorcontrib><title>Monoterpenoid Quinoline Alkaloids from Stems and Leaves of Melodinus tenuicaudatus</title><title>Chemistry & biodiversity</title><description>Two previously undescribed monoterpenoid quinoline alkaloids, namely melotenucadines A and B, together with four known analogs, were characterized from the stems and leaves of Melodinus tenuicaudatus. The structures of the new compounds were established by extensive MS and NMR spectroscopic methods, while the absolute configuration was conducted by ECD calculations. Melotenucadine B was found to show certain cytotoxicity to MCF‐7 cell (IC50=27.3 μM).</description><subject>Absolute configuration</subject><subject>Alkaloids</subject><subject>Cytotoxicity</subject><subject>Leaves</subject><subject>Melodinus tenuicaudatus</subject><subject>melotenucadines A and B</subject><subject>monoterpenoid quinoline alkaloids</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Quinoline</subject><subject>Toxicity</subject><issn>1612-1872</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkNtLwzAUxosoOKevPgd88aUzlzZpH-e8wkS8vpY0PYXMNJlNM9l_b8Zkgi_CgXPh930cviQ5JXhCMKYXqm5WE4opjQsu95IR4YSmpCjw_m4W9DA58n4RkXgvRsnzg7NugH4J1ukGPQVtndEW0NR8SBNPHrW969DLAJ1H0jZoDnIFHrkWPYBxjbbBowFs0EqGRg7BHycHrTQeTn76OHm7uX6d3aXzx9v72XSeKpbjMuUlcMhbIRiBrIZcKFbUbY4ZKfKyqTMuWBZLFpiTVjY44yQTghNFa0oVYWycnG99l737DOCHqtNegTHSggu-olyUlAlC84ie_UEXLvQ2fhepMsM85-XGcLKlVO-876Gtlr3uZL-uCK42EVebiKtdxFFQbgVf2sD6H7qaXV69_2q_AfZffow</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Wu, Feng</creator><creator>Chen, Yi</creator><creator>Yin, Jie‐Lin</creator><creator>Zhu, Cun‐Hui</creator><creator>Zhang, Yan</creator><creator>Liu, Ji‐Kai</creator><creator>He, Juan</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6682-5481</orcidid></search><sort><creationdate>202207</creationdate><title>Monoterpenoid Quinoline Alkaloids from Stems and Leaves of Melodinus tenuicaudatus</title><author>Wu, Feng ; Chen, Yi ; Yin, Jie‐Lin ; Zhu, Cun‐Hui ; Zhang, Yan ; Liu, Ji‐Kai ; He, Juan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3509-69e6e5f7731e4be57c38bf5031859db46734734a8061fad046147761c2b22c133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Absolute configuration</topic><topic>Alkaloids</topic><topic>Cytotoxicity</topic><topic>Leaves</topic><topic>Melodinus tenuicaudatus</topic><topic>melotenucadines A and B</topic><topic>monoterpenoid quinoline alkaloids</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Quinoline</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Feng</creatorcontrib><creatorcontrib>Chen, Yi</creatorcontrib><creatorcontrib>Yin, Jie‐Lin</creatorcontrib><creatorcontrib>Zhu, Cun‐Hui</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Liu, Ji‐Kai</creatorcontrib><creatorcontrib>He, Juan</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry & biodiversity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Feng</au><au>Chen, Yi</au><au>Yin, Jie‐Lin</au><au>Zhu, Cun‐Hui</au><au>Zhang, Yan</au><au>Liu, Ji‐Kai</au><au>He, Juan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monoterpenoid Quinoline Alkaloids from Stems and Leaves of Melodinus tenuicaudatus</atitle><jtitle>Chemistry & biodiversity</jtitle><date>2022-07</date><risdate>2022</risdate><volume>19</volume><issue>7</issue><spage>e202200209</spage><epage>n/a</epage><pages>e202200209-n/a</pages><issn>1612-1872</issn><eissn>1612-1880</eissn><abstract>Two previously undescribed monoterpenoid quinoline alkaloids, namely melotenucadines A and B, together with four known analogs, were characterized from the stems and leaves of Melodinus tenuicaudatus. The structures of the new compounds were established by extensive MS and NMR spectroscopic methods, while the absolute configuration was conducted by ECD calculations. Melotenucadine B was found to show certain cytotoxicity to MCF‐7 cell (IC50=27.3 μM).</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/cbdv.202200209</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6682-5481</orcidid></addata></record> |
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| ispartof | Chemistry & biodiversity, 2022-07, Vol.19 (7), p.e202200209-n/a |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Absolute configuration Alkaloids Cytotoxicity Leaves Melodinus tenuicaudatus melotenucadines A and B monoterpenoid quinoline alkaloids NMR Nuclear magnetic resonance Quinoline Toxicity |
| title | Monoterpenoid Quinoline Alkaloids from Stems and Leaves of Melodinus tenuicaudatus |
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