Monoterpenoid Quinoline Alkaloids from Stems and Leaves of Melodinus tenuicaudatus

Monoterpenoid Quinoline Alkaloids from Stems and Leaves of Melodinus tenuicaudatus

Two previously undescribed monoterpenoid quinoline alkaloids, namely melotenucadines A and B, together with four known analogs, were characterized from the stems and leaves of Melodinus tenuicaudatus. The structures of the new compounds were established by extensive MS and NMR spectroscopic methods,...

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Veröffentlicht in:Chemistry & biodiversity 2022-07, Vol.19 (7), p.e202200209-n/a
Hauptverfasser: Wu, Feng, Chen, Yi, Yin, Jie‐Lin, Zhu, Cun‐Hui, Zhang, Yan, Liu, Ji‐Kai, He, Juan
Format: Artikel
Sprache:eng
Schlagworte:
Absolute configuration
Alkaloids
Cytotoxicity
Leaves
Melodinus tenuicaudatus
melotenucadines A and B
monoterpenoid quinoline alkaloids
NMR
Nuclear magnetic resonance
Quinoline
Toxicity
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Beschreibung
Zusammenfassung:Two previously undescribed monoterpenoid quinoline alkaloids, namely melotenucadines A and B, together with four known analogs, were characterized from the stems and leaves of Melodinus tenuicaudatus. The structures of the new compounds were established by extensive MS and NMR spectroscopic methods, while the absolute configuration was conducted by ECD calculations. Melotenucadine B was found to show certain cytotoxicity to MCF‐7 cell (IC50=27.3 μM).
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202200209