Effects of losartan and exercise on muscle mass and exercise endurance of old mice

This study evaluated the effects of angiotensin II type I receptor blocker (ARB) on muscle mass and exercise capacity in healthy older animals. The effects of combined ARB and exercise training were also determined. Eighty 18-month-old mice were randomized into the control group (C), exercise group...

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Veröffentlicht in:Experimental gerontology 2022-08, Vol.165, p.111869-111869, Article 111869
Hauptverfasser: Lin, Chung-Hao, Chang, Po-Cheng, Chu, Pao-Hsien, Chuang, Yi-Fang, Huang, Rong-Chi, Chen, Chiao-Nan
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Sprache:eng
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Zusammenfassung:This study evaluated the effects of angiotensin II type I receptor blocker (ARB) on muscle mass and exercise capacity in healthy older animals. The effects of combined ARB and exercise training were also determined. Eighty 18-month-old mice were randomized into the control group (C), exercise group (E), losartan group (L) and losartan plus exercise group (LE). Mice in the L and LE groups received losartan from drinking water every day. Mice in the E and LE groups trained on a treadmill 30 min per day, 3 days per week for 4 months. Exercise endurance and spontaneous physical activity of mice were measured at baseline and monthly for 4 months. After 4 months of intervention, serum interleukin-6 (IL-6) levels, muscle mass, and muscle fiber cross sectional area (CSA) were measured. Total antioxidant capacity (TAC), lipid peroxidation and IL-6 levels were determined in quadriceps. We found that exercise endurance only increased in the E and LE groups. Muscle TAC levels of E, L, and LE groups were greater than that in the C group. Serum IL-6 and lipid peroxidation levels were not different among groups. LE group, but not E and L groups, had greater muscle mass, larger muscle fiber CSA, and greater muscle IL-6 levels than that in the C group after 4 months of intervention. These results suggest that losartan promotes the adaptions of muscle mass with exercise training in healthy older animals. •Losartan promotes the increase of muscle IL-6 levels and muscle mass in old animals with exercise training.•Losartan does not provide additive effects on exercise endurance in old animals with exercise training.•Losartan intervention alone neither increases exercise endurance nor increases muscle size in old animals.•Both losartan and exercise training increase muscle total antioxidant capacity of old animals.
ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2022.111869