The discordant biomarker dilemma: What are the diagnostic implications of oropharyngeal squamous cell carcinomas with discrepant p16 and HPV results?

The discordant biomarker dilemma: What are the diagnostic implications of oropharyngeal squamous cell carcinomas with discrepant p16 and HPV results?

Discordant p16 and human papillomavirus (HPV)‐specific testing results, although uncommon in oropharyngeal squamous cell carcinomas, present a quandary to pathologists and treating clinicians alike. This commentary outlines potential scenarios leading to p16/HPV discordance and highlights recent stu...

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Veröffentlicht in:Cancer cytopathology 2022-11, Vol.130 (11), p.844-848
Hauptverfasser: Guzmán‐Arocho, Yaileen D., Nishino, Michiya
Format: Artikel
Sprache:eng
Schlagworte:
Squamous cell carcinoma
Throat cancer
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Zusammenfassung:Discordant p16 and human papillomavirus (HPV)‐specific testing results, although uncommon in oropharyngeal squamous cell carcinomas, present a quandary to pathologists and treating clinicians alike. This commentary outlines potential scenarios leading to p16/HPV discordance and highlights recent studies that shed some light on the prognostic significance thereof.
ISSN:1934-662X
1934-6638
DOI:10.1002/cncy.22616